|Chemical and physical data|
|Molar mass||347.42 g/mol|
|3D model (Jmol)||Interactive image|
Fluotracen (SKF-28,175) is a tricyclic drug which possesses dual antidepressant and antipsychotic activity. This profile of effects is similar to that of related agents like amoxapine, loxapine, and trimipramine which may also be used in the treatment of both depression and psychosis. It was believed that such duality would be advantageous in the treatment of schizophrenia, as depression is often comorbid with the disorder (i.e., negative symptoms), and usual antipsychotics often worsen such symptoms. In any case, however, fluotracen was never marketed.
- Annual Reports in Medicinal Chemistry: v. 14. Academic Press Inc.,U.S. 1979. ISBN 0-12-040514-8.
- Fowler PJ, Zirkle CL, Macko E, et al. (1977). "Fluotracen: a tricyclic compound with the combined properties of antidepressants and antipsychotics in animals". Arzneimittel-Forschung. 27 (8): 1589–95. PMID 410422.
- David J. Triggle (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9.
|α2δ VDCC blockers|
(TCAs and TeCAs)