Synonyms Phenethazinum, Phenethazine, Phenetazine; RP-3015, SC-1627, WY-1143
CAS Number 208-325-1 YesY
PubChem (CID) 68223
ChemSpider 61526 YesY
KEGG D02602
Chemical and physical data
Formula C16H18N2S
Molar mass 270.39 g/mol
3D model (Jmol) Interactive image

Fenethazine (INN) (brand names Anergen, Contralergial, Ethysine, Etisine, Lisergan, Lysergan; former developmental code names RP-3015, SC-1627, WY-1143), also known as phenethazinum, is a first-generation antihistamine of the phenothiazine group.[1] Promethazine, and subsequently chlorpromazine, were derived from fenethazine.[2] Fenethazine, in turn, was derived from phenbenzamine.[3]


  1. J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 434–. ISBN 978-1-4757-2085-3.
  2. Florencio Zaragoza Dörwald (4 February 2013). Lead Optimization for Medicinal Chemists: Pharmacokinetic Properties of Functional Groups and Organic Compounds. John Wiley & Sons. pp. 301–. ISBN 978-3-527-64565-7.
  3. Walter Sneader (23 June 2005). Drug Discovery: A History. John Wiley & Sons. pp. 404–. ISBN 978-0-471-89979-2.

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