Distigmine bromide
Clinical data
Routes of
oral, i.m.
ATC code N07AA03 (WHO)
Pharmacokinetic data
Bioavailability 4.65 % [1]
Biological half-life 65 h [1]
Excretion renal [1]
CAS Number 15876-67-2
PubChem (CID) 27522
ChemSpider 25613 YesY
UNII T940307O7B YesY
KEGG D01228
ECHA InfoCard 100.036.360
Chemical and physical data
Formula C22H32Br2N4O4
Molar mass 576.322 g/mol
3D model (Jmol) Interactive image

Distigmine (as distigmine bromide) is a parasympathomimetic. Distigmine is similar to pyridostigmine and neostigmine but has a longer duration of action. It is available as tablets on prescription only. Distigmine has a greater risk of causing cholinergic crisis because of accumulation of the drug being more likely than with neostigmine or pyridostigmine and so distigmine is rarely used as a treatment for myasthenia gravis, unlike pyridostigmine and neostigmine.


  1. 1 2 3 The Japanese Pharmacopoeia, Edition 14/I: Official Monographs, Yakuji Nippo. Ltd., Tokyo (2001), ISBN 978-4840806725, Page 599.

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