PubChem (CID) 9891642
ChemSpider 8067312
Chemical and physical data
Formula C31H38FN3O
Molar mass 487.651
3D model (Jmol) Interactive image

DPI-221 is a opioid drug that is used in scientific research. It is a highly selective agonist for the δ-opioid receptor, which produces fewer convulsions than most drugs from this family.[1]


  1. Holt, JD; Watson, MJ; Chang, JP; O'Neill, SJ; Wei, K; Pendergast, W; Gengo, PJ; Chang, KJ (2005). "DPI-221 4-((alpha-s)-alpha-((2s,5r)-2,5-dimethyl-4-(3-fluorobenzyl)-1-piperazinyl)benzyl)-N,N-diethylbenzamide: a novel nonpeptide delta receptor agonist producing increased micturition interval in normal rats". The Journal of Pharmacology and Experimental Therapeutics. 315 (2): 601–8. doi:10.1124/jpet.105.090498. PMID 16020629.

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