Symbol Latrophilin
Pfam PF02354
InterPro IPR003334
EGF, latrophilin and seven transmembrane domain containing 1
Symbol ELTD1
Alt. symbols ETL
Entrez 64123
HUGO 20822
RefSeq NM_022159
UniProt Q9HBW9
Other data
Locus Chr. 1 p33-p32
latrophilin 1
Symbol LPHN1
Alt. symbols KIAA0821, CIRL1, LEC2
Entrez 22859
HUGO 20973
RefSeq NM_014921
UniProt O94910
Other data
Locus Chr. 19 p13.2
latrophilin 2
Symbol LPHN2
Alt. symbols LPHH1, KIAA0786, LEC1
Entrez 23266
HUGO 18582
OMIM 607018
RefSeq NM_012302
UniProt O95490
Other data
Locus Chr. 1 p31.1
latrophilin 3
Symbol LPHN3
Alt. symbols KIAA0768, LEC3
Entrez 23284
HUGO 20974
RefSeq NM_015236
UniProt Q9HAR2
Other data
Locus Chr. 4 q13.1

Latrophilins are a group of highly conserved G-protein coupled receptors from the adhesion G protein-coupled receptor family. These receptors were originally identified based on their ability to bind the spider venom alpha-latrotoxin.[1] This conserved family of membrane proteins has up to three homologues in chordate species, including humans.[2]

The precise functions of latrophilins remain unknown.[2] Genetic defects in latrophilin genes have been associated with diseases such as attention-deficit hyperactivity disorder and cancer.[3]

Human proteins containing this domain

See also


  1. Kreienkamp HJ, Soltau M, Richter D, Böckers T (2002). "Interaction of G-protein-coupled receptors with synaptic scaffolding proteins". Biochem. Soc. Trans. 30 (4): 464–8. doi:10.1042/BST0300464. PMID 12196116.
  2. 1 2 Silva, JP; Ushkaryov, YA (2010). "The latrophilins, "split-personality" receptors.". Advances in Experimental Medicine and Biology. 706: 59–75. PMC 3145135Freely accessible. PMID 21618826.
  3. Meza-Aguilar, Diana G; Boucard, Antony A (1 January 2014). "Latrophilins updated". Biomolecular Concepts. 5 (6). doi:10.1515/bmc-2014-0032.
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