HEPPS (molecule)

IUPAC name
3-[4-(2-Hydroxyethyl)piperazin-1-yl]propane-1-sulfonic acid
Other names
3D model (Jmol) Interactive image
ChEBI CHEBI:42298 YesY
ChemSpider 76886 YesY
ECHA InfoCard 100.036.528
PubChem 85255
Molar mass 252.33 g·mol−1
Melting point (decomposes)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

HEPPS or EPPS are the common names for the compound 3-[4-(2-Hydroxyethyl)-1-piperazinyl]propanesulfonic acid. It is used as a buffering agent in biology and biochemistry. The pKa of HEPPS is 8.00. Research on mice with Alzheimers disease-like [[Amyloid beta ]] plaques has shown that the EPPS can cause the plaques to break up, reversing some of the symptoms in the mice.[1][2]


  1. "Small Molecule Breaks Up Amyloid Aggregates In Mice | Chemical & Engineering News". cen.acs.org. Retrieved 14 December 2015.
  2. Kim, Hye Yun; Kim, Hyunjin Vincent; Jo, Seonmi; Lee, C. Justin; Choi, Seon Young; Kim, Dong Jin; Kim, YoungSoo (8 December 2015). "EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques". Nature Communications. 6: 8997. doi:10.1038/ncomms9997.

See also

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