Clinical data
AHFS/ Micromedex Detailed Consumer Information
  • US: N (Not classified yet)
ATC code R06AX04 (WHO)
Legal status
Legal status
CAS Number 82-88-2 YesY
PubChem (CID) 11291
DrugBank DB01619 N
ChemSpider 10817 N
KEGG D08353 YesY
ECHA InfoCard 100.001.313
Chemical and physical data
Formula C19H19N
Molar mass 261.361 g/mol
3D model (Jmol) Interactive image
 NYesY (what is this?)  (verify)

Phenindamine (Nolahist, Thephorin) is an antihistamine and anticholinergic closely related to cyproheptadine. It was developed by Hoffman-La Roche in the late 1940s.[1] It is used to treat symptoms of the common cold and allergies, such as sneezing, itching, rashes, and hives. Its efficacy against some symptoms of opioid withdrawal was researched in the 1950s and 1960s in a number of countries; William S. Burroughs' book Junkie mentions this technique. Like many other first-generation antihistamines, phenindamine has useful potentiating effects on many narcotic analgesics and is even more useful with those opioids which release histamine when in the body.

Nolahist was originally manufactured in the USA by Carnrick Laboratories, and later by Amarin Pharmaceuticals. When that company ceased its American operations, its product line was acquired by Valeant, but they declined to resume manufacturing Nolahist. The last produced lot bore an expiration date of 10/2005, and the product is no longer available.

See also


  1. US Patent 2546652 - Pyridindenes and process for their manufacture
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