Clinical data
Trade names Onon (オノン)
AHFS/ International Drug Names
Routes of
ATC code R03DC02 (WHO)
Pharmacokinetic data
Metabolism Hepatic (mainly CYP3A4)[1]
Biological half-life 1.5 hours[1]
CAS Number 103177-37-3 YesY
PubChem (CID) 4887
DrugBank DB01411 YesY
ChemSpider 4718 YesY
UNII TB8Z891092 YesY
ECHA InfoCard 100.236.084
Chemical and physical data
Formula C27H23N5O4
Molar mass 481.503 g/mol
3D model (Jmol) Interactive image

Pranlukast (brand name Onon, オノン) is a cysteinyl leukotriene receptor-1 antagonist. This drug works similarly to Merck & Co.'s montelukast (Singulair). It is widely used in Japan.

Medications of this class, which go under a variety of names according to whether one looks at the American, British or European system of nomenclature, have as their primary function the antagonism of bronchospasm caused, principally in asthmatics, by an allergic reaction to accidentally or inadvertently encountered allergens.[2]

Medications of this group are normally used as an adjunct to the standard therapy of inhaled steroids with inhaled long- and/or short-acting beta-agonists. There are several similar medications in the group; all appear to be equally effective.


  1. 1 2 Nakade S, Ueda S, Ohno T, Nakayama K, Miyata Y, Yukawa E, Higuchi S (2006). "Population pharmacokinetics of pranlukast hydrate dry syrup in children with allergic rhinitis and bronchial asthma.". Drug Metab Pharmacokinet. 21 (2): 133–9. doi:10.2133/dmpk.21.133. PMID 16702733.
  2. Singh, Rakesh Kumar; Tandon, Ruchi; Dastidar, Sunanda Ghosh; Ray, Abhijit (2013). "A review on leukotrienes and their receptors with reference to asthma". Journal of Asthma. 50 (9): 922–931. doi:10.3109/02770903.2013.823447. ISSN 0277-0903.
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