Clinical data
ATC code N05CA22 (WHO)
Synonyms Proxibarbital, Centralgol, Ipronal, 5-Allyl-5-(β-hydroxypropyl)barbituric acid
CAS Number 2537-29-3 N
PubChem (CID) 17336
ChemSpider 16406 YesY
ECHA InfoCard 100.018.004
Chemical and physical data
Formula C10H14N2O4
Molar mass 226.229 g/mol
3D model (Jmol) Interactive image
 NYesY (what is this?)  (verify)

Proxibarbital (Ipronal) is a barbiturate derivative synthesized in 1956. It has anti-anxiety properties and in contrast to most barbiturates almost without hypnotic action.[1]

It was also used in the treatment of migraine headaches in a similar manner to butalbital.[2]

Valofane tautomerises to Proxibarbal in vivo.


  1. Zajdel, P.; Kulig, K.; Zejc, A. (2008). Zejc, A.; Gorczyca, M., eds. Chemia leków, podręcznik dla studentów farmacji i farmaceutów (in Polish). Warszawa, Poland. ISBN 978-83-200-3652-7.
  2. Sulman, F. G.; Pfeifer, Y.; Tal, E. (1976). "Migraine therapy by enzyme induction with proxibarbital". Therapie der Gegenwart (in German). 115 (12): 2088–2103. PMID 14412.

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