Clinical data
AHFS/ International Drug Names
ATC code M03BX06 (WHO)
CAS Number 59-47-2 N
PubChem (CID) 4059
ChemSpider 3919 YesY
UNII 7B8PIR2954 YesY
KEGG D02595 YesY
NIAID ChemDB 017830
ECHA InfoCard 100.000.389
Chemical and physical data
Formula C10H14O3
Molar mass 182.216 g/mol
3D model (Jmol) Interactive image
 NYesY (what is this?)  (verify)

Mephenesin is a centrally acting muscle relaxant. It can be used as an antidote for strychnine poisoning. Mephenesin however presents with the major drawbacks of having a short duration of action and a much greater effect on the spinal cord than the brain, resulting in pronounced respiratory depression at clinical doses and therefore a very low therapeutic index. It is especially dangerous and potentially fatal in combination with alcohol and other depressants.[1] Mephenesin was used by Dr. Bernard Ludwig and Dr. Frank Milan Berger to synthesize meprobamate, the first tranquilizer to see widespread clinical use. Mephenesin is no longer available in North America but is used in France, Italy and a few other countries.[2] Its use has largely been replaced by the related drug methocarbamol, which is better absorbed[3]

Mephenesin may be an NMDA receptor antagonist.[4]

See also


  1. "Mephenesin". MIMS.
  2. "Mephenesin".
  3. Huf, Ernst; et al. "Comparative Plasma Levels of Mephenesin, Mephenesin Carbamate and Methocarbamol". Experimental Biology & Medicine. Retrieved 8 January 2014.
  4. Keshavarz M, Showraki A, Emamghoreishi M (2013). "Anticonvulsant Effect of Guaifenesin against Pentylenetetrazol-Induced Seizure in Mice". Iran J Med Sci. 38 (2): 116–21. PMC 3700057Freely accessible. PMID 23825891.

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