Clinical data
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Legal status
Legal status
  • Uncontrolled
CAS Number 83166-18-1
PubChem (CID) 6450479
ChemSpider 4953084
Chemical and physical data
Formula C27H28N4O4
Molar mass 472.54 g/mol
3D model (Jmol) Interactive image

Tampramine (AHR-9,377) is a tricyclic antidepressant (TCA) which was developed in the 1980s but was never marketed.[1][2] Despite being a TCA, it acts as a selective norepinephrine reuptake inhibitor and has negligible affinity for adrenergic, histaminergic, and muscarinic receptors.[1] It was found to be effective in the forced swim test (FST) model of depression in animal studies but is not known to have ever been trialed in humans.[2]

See also


  1. 1 2 Kinnier WJ, Tabor RD, Norrell LY (October 1984). "Neurochemical properties of AHR-9377: a novel inhibitor of norepinephrine reuptake". Biochemical Pharmacology. 33 (19): 3001–5. doi:10.1016/0006-2952(84)90600-2. PMID 6548381.
  2. 1 2 O'Donnell JM, Seiden LS (1985). "Effect of the experimental antidepressant AHR-9377 on performance during differential reinforcement of low response rate". Psychopharmacology. 87 (3): 283–5. doi:10.1007/BF00432708. PMID 3936083.
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