PubChem (CID) 5311079
ChemSpider 4470613 N
Chemical and physical data
Formula C7H13NO4
Molar mass 175.182 g/mol
3D model (Jmol) Interactive image
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(2S)-α-Ethylglutamic acid (EGLU) is a drug that is used in neuroscience research. It was one of the first compounds found that acts as a selective antagonist for the group II metabotropic glutamate receptors (mGluR2/3), and so has been useful in the characterisation and study of this receptor subfamily.[1][2][3][4][5][6][7]


  1. Jane, DE; Thomas, NK; Tse, HW; Watkins, JC (1996). "Potent antagonists at the L-AP4- and (1S,3S)-ACPD-sensitive presynaptic metabotropic glutamate receptors in the neonatal rat spinal cord". Neuropharmacology. 35 (8): 1029–35. doi:10.1016/S0028-3908(96)00048-2. PMID 9121605.
  2. Huang, L; Rowan, MJ; Anwyl, R (1999). "Induction of long-lasting depression by (+)-alpha-methyl-4-carboxyphenylglycine and other group II mGlu receptor ligands in the dentate gyrus of the hippocampus in vitro". European Journal of Pharmacology. 366 (2–3): 151–8. doi:10.1016/S0014-2999(98)00918-2. PMID 10082195.
  3. Palazzo, E; Marabese, I; De Novellis, V; Oliva, P; Rossi, F; Berrino, L; Rossi, F; Maione, S (2001). "Metabotropic and NMDA glutamate receptors participate in the cannabinoid-induced antinociception". Neuropharmacology. 40 (3): 319–26. doi:10.1016/S0028-3908(00)00160-X. PMID 11166324.
  4. Iserhot, C; Gebhardt, C; Schmitz, D; Heinemann, U (2004). "Glutamate transporters and metabotropic receptors regulate excitatory neurotransmission in the medial entorhinal cortex of the rat". Brain Research. 1027 (1–2): 151–60. doi:10.1016/j.brainres.2004.08.052. PMID 15494166.
  5. Cahusac, PM; Wan, H (2007). "Group II metabotropic glutamate receptors reduce excitatory but not inhibitory neurotransmission in rat barrel cortex in vivo". Neuroscience. 146 (1): 202–12. doi:10.1016/j.neuroscience.2007.01.049. PMID 17346894.
  6. Kim, WY; Vezina, P; Kim, JH (2008). "Blockade of group II, but not group I, mGluRs in the rat nucleus accumbens inhibits the expression of conditioned hyperactivity in an amphetamine-associated environment". Behavioural Brain Research. 191 (1): 62–6. doi:10.1016/j.bbr.2008.03.010. PMID 18433894.
  7. Altinbilek, B; Manahan-Vaughan, D (2009). "A specific role for group II metabotropic glutamate receptors in hippocampal long-term depression and spatial memory". Neuroscience. 158 (1): 149–58. doi:10.1016/j.neuroscience.2008.07.045. PMID 18722513.

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