IUPAC name
Amino(2-chloro-5-hydroxyphenyl)acetic acid
170846-74-9 YesY
1303993-73-8 (sodium salt) YesY
3D model (Jmol) Interactive image
Abbreviations CHPG
ChemSpider 2879711
ECHA InfoCard 100.162.133
PubChem 3645780
Molar mass 199.59 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

2-Chloro-5-hydroxyphenylglycine or CHPG is an agonist of the metabotropic glutamate receptors, specific for mGluR5.[1]

It is capable of directly potentiating the depolarization of hippocampal CA1 neurons induced through NMDA administration.[2]


  1. Kammermeier, Paul J (2012). "The orthosteric agonist 2-chloro-5-hydroxyphenylglycine activates mGluR5 and mGluR1 with similar efficacy and potency". BMC Pharmacology. 12: 6. doi:10.1186/1471-2210-12-6. PMC 3416681Freely accessible. PMID 22642439.
  2. Collingridge G.; Volianskis A.; Bannister N.; France G.; Hanna L.; Mercier M.; Tidball P.; Fang G.; Irvine M.; Costa, Blaise M.; Monaghan, Daniel T.; Bortolotto, Zuner A.; Molnár, Elek; Lodge, David; Jane, David E. (2013). "The NMDA receptor as a target for cognitive enhancement". Neuropharmacology. 64: 13–26. doi:10.1016/j.neuropharm.2012.06.051. PMID 22796429.

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