Esterified estrogen

Estrone sulfate, the primary active agent of esterified estrogen products.

Esterified estrogens (EEs) (brand names Amnestrogen, Estratab, Estratest, Evex, Femogen, Menest) are synthetic, plant-based estrogens that are manufactured from soybeans and yams.[1][2] They are used in hormone replacement therapy for menopausal symptoms, female hypogonadism, ovariectomy, and primary ovarian failure and in the treatment of prostate cancer.[3]

EEs consist primarily of sodium estrone sulfate and sodium equilin sulfate, and are very similar to conjugated equine estrogen (CEE) preparations such as Premarin.[2][4][5] However, EEs and CEEs differ in the sources of their contents and in the percentages of their constituents; CEEs consist of approximately 53% sodium estrone sulfate and 25% sodium equilin sulfate, while EEs contain approximately 80% sodium estrone sulfate and 11% sodium equilin sulfate.[4][6][3] EEs and CEEs have been found to produce similar serum levels of estrone and estradiol.[7] One study found that the risk of venous thrombosis may be less with EEs relative to CEEs.[6][2]

Estratest is a combination formulation of 1.25 mg EEs with 2.5 mg methyltestosterone.[8]

See also


  1. Carl P. Weiner, MD; Kate Rope (2 April 2013). The Complete Guide to Medications During Pregnancy and Breastfeeding: Everything You Need to Know to Make the Best Choices for You and Your Baby. St. Martin's Press. pp. 179–. ISBN 978-0-312-67646-9.
  2. 1 2 3 Smith, N. L.; Heckbert, S. R.; Lemaitre, R. N.; Reiner, A. P.; Lumley, T.; Rosendaal, F. R.; Psaty, B. M. (2006). "Conjugated Equine Estrogen, Esterified Estrogen, Prothrombotic Variants, and the Risk of Venous Thrombosis in Postmenopausal Women". Arteriosclerosis, Thrombosis, and Vascular Biology. 26 (12): 2807–2812. doi:10.1161/01.ATV.0000245792.62517.3b. ISSN 1079-5642.
  3. 1 2 Manuchair Ebadi (31 October 2007). Desk Reference of Clinical Pharmacology, Second Edition. CRC Press. pp. 249–. ISBN 978-1-4200-4744-8.
  4. 1 2 Marc A. Fritz; Leon Speroff (28 March 2012). Clinical Gynecologic Endocrinology and Infertility. Lippincott Williams & Wilkins. pp. 752–. ISBN 978-1-4511-4847-3.
  5. Tara Parker-Pope (9 January 2007). The Hormone Decision: Untangle the Controversy, Understand Your Options, Make Your Own Choices. Rodale. pp. 157–. ISBN 978-1-59486-927-3.
  6. 1 2 Smith, Nicholas L. (2004). "Esterified Estrogens and Conjugated Equine Estrogens and the Risk of Venous Thrombosis". JAMA. 292 (13): 1581. doi:10.1001/jama.292.13.1581. ISSN 0098-7484.
  7. Lemaitre, Rozenn N.; Weiss, Noel S.; Smith, Nicholas L.; Psaty, Bruce M.; Lumley, Thomas; Larson, Eric B.; Heckbert, Susan R. (2006). "Esterified Estrogen and Conjugated Equine Estrogen and the Risk of Incident Myocardial Infarction and Stroke". Archives of Internal Medicine. 166 (4): 399. doi:10.1001/archinte.166.4.399. ISSN 0003-9926.
  8. John E. Morley; Lucretia van den Berg (5 November 1999). Endocrinology of Aging. Springer Science & Business Media. pp. 172–. ISBN 978-1-59259-715-4.

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