Estradiol phenylpropionate

Estradiol phenylpropionate
Synonyms Estradiol phenpropionate, estradiol benzenepropionate, estradiol phenylpropanoate, estradiol benzenepropanoate
CAS Number 26443-03-8
PubChem (CID) 68577
ChemSpider 61847
Chemical and physical data
Formula C27H32O3
Molar mass 404.54118 g/mol
3D model (Jmol) Interactive image

Estradiol phenylpropionate (EPP), also known as estradiol 17β-phenylpropionate, is a semisynthetic, steroidal estrogen.[1][2] It is the phenylpropionate ester of estradiol.[1] EPP is marketed in combination with estradiol benzoate under the brand name Dimenformon Prolongatum in the Netherlands and in combination with estradiol benzoate, testosterone propionate, testosterone phenylpropionate, and testosterone isocaproate under the brand name Mixogen (a balanced mixture of estradiol and testosterone esters).[1][2] Both of these drug combinations are long-acting injectables indicated in hormone replacement therapy for women in menopause. Dimenformon Prolongatum has also been investigated as a single injection, "morning after" post-coital contraceptive, and is additionally used as a component of hormone replacement therapy for transgender women.[2]


  1. 1 2 3 Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 406–. ISBN 978-3-88763-075-1.
  2. 1 2 3 Vincenzo Mirone (12 February 2015). Clinical Uro-Andrology. Springer. pp. 17–. ISBN 978-3-662-45018-5.

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