Estradiol hemisuccinate

Not to be confused with Estriol succinate.
Estradiol hemisuccinate
Clinical data
Trade names Eutocol
CAS Number 7698-93-3
PubChem (CID) 66440
DrugBank DB07891
ChemSpider 59813
Chemical and physical data
Formula C22H28O5
Molar mass 372.46 g/mol
3D model (Jmol) Interactive image

Estradiol hemisuccinate (brand name Eutocol), or simply estradiol succinate, also known as estradiol 17β-hemisuccinate, is a semisynthetic, steroidal estrogen and an estrogen ester – specifically, the hemisuccinate ester of estradiol.[1] It is used as a component of hormone replacement therapy for menopause.[2] Like other estrogens, estradiol hemisuccinate has been found to have beneficial effects on the skin, with improvement of skin thickness observed.[3][4]

See also


  1. J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. p. 897. ISBN 978-1-4757-2085-3.
  2. Miranda A. Farage; Kenneth W. Miller; Howard I. Maibach (2 December 2009). Textbook of Aging Skin. Springer Science & Business Media. pp. 362–. ISBN 978-3-540-89655-5.
  3. Thompson, Zack; Maibach, Howard I. (2010). "Biological Effects of Estrogen on Skin": 361–367. doi:10.1007/978-3-540-89656-2_35.
  4. Maheux R, Naud F, Rioux M, Grenier R, Lemay A, Guy J, Langevin M (1994). "A randomized, double-blind, placebo-controlled study on the effect of conjugated estrogens on skin thickness". Am. J. Obstet. Gynecol. 170 (2): 642–9. PMID 8116726.

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