Ethinyl estriol

Not to be confused with ethinyl estradiol.
Ethinyl estriol
Clinical data
Routes of
Synonyms EE3; 17α-Ethynylestriol; 17α-Ethynylestra-1,3,5(10)-triene-3,16α,17β-triol
CAS Number 4717-40-2
PubChem (CID) 11723045
ChemSpider 9897761
Chemical and physical data
Formula C20H24O3
Molar mass 312.409 g/mol
3D model (Jmol) Interactive image

Ethinyl estriol (EE3), or 17α-ethynylestriol, also known as 17α-ethynylestra-1,3,5(10)-triene-3,16α,17β-triol, is a synthetic, steroidal estrogen that was never marketed.[1] Nilestriol, the 3-cyclopentyl ether of ethinyl estriol, is a prodrug of ethinyl estriol, and is a more potent estrogen in comparison,[1] but, similarly to ethinyl estriol, was never marketed.[2] Ethinyl estriol has been found to reduce the risk of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary cancer when given as a prophylactic in animal models, while other estrogens like ethinyl estradiol and diethylstilbestrol were ineffective.[3]

See also


  1. 1 2 William McGuire (14 December 2013). Experimental Biology. Springer Science & Business Media. pp. 161–. ISBN 978-1-4757-4673-0.
  2. J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 891–. ISBN 978-1-4757-2085-3.
  3. Lemon, Henry M. (15 December 1987). "Antimammary carcinogenic activity of 17-alpha-ethinyl estriol". Cancer. 60 (12): 2873–2881. doi:10.1002/1097-0142(19871215)60:12<2873::AID-CNCR2820601204>3.0.CO;2-B. ISSN 1097-0142. PMID 3119187.

This article is issued from Wikipedia - version of the 12/4/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.