CAS Number 116057-75-1
PubChem (CID) 3034011
ChemSpider 2298565
UNII 456UXE9867 YesY
Chemical and physical data
Formula C28H30INO
Molar mass 523.4 g/mol
3D model (Jmol) Interactive image

Idoxifene is a non-steroidal estrogen antagonist.[1] It is structurally analogous to tamoxifen.

A large-scale synthesis has been devised.[2]


  1. McCague, R; Leclercq, G; Legros, N; Goodman, J; Blackburn, GM; Jarman, M; Foster, AB (1989). "Derivatives of tamoxifen. Dependence of antiestrogenicity on the 4-substituent". Journal of Medicinal Chemistry. 32 (12): 2527–33. doi:10.1021/jm00132a006. PMID 2585441.
  2. McCague, Raymond; Potter, Gerard A.; Jarman, Michael (1994). "AN EFFICIENT, LARGE-SCALE SYNTHESIS OF IDOXIFENE {(E)-1-[4-[2-(N-PYRROLIDINO)ETHOXY]PHENYL]-1-(4-IODOPHENYL)-2-PHENYL-1-BUTENE}". Organic Preparations and Procedures International. 26 (3): 343–346. doi:10.1080/00304949409458432. ISSN 0030-4948.

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