Clinical data
ATC code G03CA09 (WHO)
Synonyms (8R,9S,13S,14S)-17-Methoxy-13-methyl-3-propoxy-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene
CAS Number 39219-28-8
PubChem (CID) 71717
ChemSpider 64767 N
Chemical and physical data
Formula C22H32O2
Molar mass 328.488 g/mol
3D model (Jmol) Interactive image

Promestriene (INN) (brand names Colpotrofin, Colpotrophine, Delipoderm), also known as estradiol 3-propyl 17β-methyl diether, is a synthetic, steroidal estrogen used topically in a 1% cream formulation.[1][2][3][4] It is the 3-propyl and 17β-methyl diether of estradiol.[5] The drug is described as a tropic agent and antiseborrheic.[1] It has not been found to be effective in the treatment of androgenic alopecia or other conditions of cutaneous androgenization.[6][7]

See also


  1. 1 2 C.R. Ganellin; David J. Triggle (21 November 1996). Dictionary of Pharmacological Agents. CRC Press. pp. 1671–. ISBN 978-0-412-46630-4.
  2. Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 1248, 1266, 1318, 1557. ISBN 978-3-88763-075-1.
  3. William Andrew Publishing (22 October 2013). Pharmaceutical Manufacturing Encyclopedia, 3rd Edition. Elsevier. pp. 270–271. ISBN 978-0-8155-1856-3.
  4. Muller (19 June 1998). European Drug Index: European Drug Registrations, Fourth Edition. CRC Press. pp. 289, 332. ISBN 978-3-7692-2114-5.
  5. Santos I, Clissold S (2010). "Urogenital disorders associated with oestrogen deficiency: the role of promestriene as topical oestrogen therapy". Gynecol. Endocrinol. 26 (9): 644–51. doi:10.3109/09513591003767948. PMID 20374067.
  6. C.E. Orfanos; W. Montagna; G. Stüttgen (6 December 2012). Hair Research: Status and Future Aspects; Proceedings of the First International Congress on Hair Research, Hamburg, March 13th–16, 1979. Springer Science & Business Media. pp. 553–. ISBN 978-3-642-81650-5.
  7. Robert Baran; Howard I. Maibach (1 October 1998). Textbook of Cosmetic Dermatology. CRC Press. pp. 493–. ISBN 978-1-85317-478-0.

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