CAS Number 547-81-9
PubChem (CID) 68929
ChemSpider 62155
Chemical and physical data
Formula C18H24O3
Molar mass 288.38136 g/mol
3D model (Jmol) Interactive image

Epiestriol (INN) (brand names Actriol, Arcagynil, Klimadoral), or epioestriol (BAN), also known as 16β-epiestriol or simply 16-epiestriol as well as 16β-hydroxy-17β-estradiol, is a minor and weak endogenous estrogen, and the 16β-epimer of estriol (which is 16α-hydroxy-17β-estradiol).[1][2] Epiestriol is (or has previously been) used clinically in the treatment of acne.[1] In addition to its estrogenic actions, epiestriol has been found to possess significant anti-inflammatory properties without glycogenic activity or immunosuppressive effects, an interesting finding that is in contrast to conventional anti-inflammatory steroids like hydrocortisone (a glucocorticoid).[3][4]

See also


  1. 1 2 J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 899–. ISBN 978-1-4757-2085-3.
  2. A. Labhart (6 December 2012). Clinical Endocrinology: Theory and Practice. Springer Science & Business Media. pp. 522–. ISBN 978-3-642-96158-8.
  3. Latman NS, Kishore V, Bruot BC (1994). "16-epiestriol: an anti-inflammatory steroid without glycogenic activity". J Pharm Sci. 83 (6): 874–7. doi:10.1002/jps.2600830623. PMID 9120824.
  4. Miller E, Bates R, Bjorndahl J, Allen D, Burgio D, Bouma C, Stoll J, Latman N (1998). "16-Epiestriol, a novel anti-inflammatory nonglycogenic steroid, does not inhibit IFN-gamma production by murine splenocytes". J. Interferon Cytokine Res. 18 (11): 921–5. doi:10.1089/jir.1998.18.921. PMID 9858313.

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