Not to be confused with Cycloguanil.
Clinical data
AHFS/ International Drug Names
Routes of
ATC code G03GB01 (WHO)
Synonyms bis(p-acetoxyphenyl)cyclohexylidenemethane
CAS Number 2624-43-3
PubChem (CID) 2898
ChemSpider 2795
UNII J468V64WZ1 YesY
KEGG D01281
ECHA InfoCard 100.018.264
Chemical and physical data
Formula C23H24O4
Molar mass 364.434 g/mol
3D model (Jmol) Interactive image

Cyclofenil (INN, USAN, BAN) (brand names Fertodur, Ondonid, Ondogyne, Sexovid, and others) is a selective estrogen receptor modulator used as a gonadotropin stimulant which is marketed in Europe, South Korea, Mexico, and Brazil, among other countries.[1][2]

Cyclofenil was studied in the 1970s as an agent to induce ovulation in infertile women.[3] It was then investigated as a possible treatment for scleroderma in the 1980s, but was found to be ineffective.[4] Later study of its efficacy in treating Raynaud's phenomenon in people with scleroderma also found no statistically significant benefit.[5]


  1. Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 284–. ISBN 978-3-88763-075-1.
  2. J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 329–. ISBN 978-1-4757-2085-3.
  3. Ruíz-Velasco V, Rosas-Arceo J, Matute MM. "Chemical inducers of ovulation: comparative results". Int J Fertil. 1979;24(1):61-4. PMID 37182.
  4. Torres MA, Furst DE (February 1990). "Treatment of generalized systemic sclerosis". Rheum Dis Clin North Am. 16 (1): 217–41. PMID 2406809.
  5. Pope J, Fenlon D, Thompson A, et al. (2000). Pope J, ed. "Cyclofenil for Raynaud's phenomenon in progressive systemic sclerosis". Cochrane Database Syst Rev (2): CD000955. doi:10.1002/14651858.CD000955. PMID 10796397.

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