Estradiol 3-propionate

Estradiol 3-propionate
Clinical data
Routes of
Intramuscular, vaginal[1]
ATC code None
Synonyms Estradiol 3-propanoate; 3,17β-Hydroxyestra-1,3,5(10)-trien-3-yl propionate
CAS Number 6045-51-8
ChemSpider 2298529
Chemical and physical data
Formula C21H28O3
Molar mass 328.44522 g/mol
3D model (Jmol) Interactive image

Estradiol 3-propionate, or 3-propanoylestradiol, also known as estra-1,3,5(10)-trien-3,17β-diol 3-propionate, is a semisynthetic, steroidal estrogen that was never marketed.[1][2] It is an estrogen ester, specifically, a propionic acid ester of estradiol, and acts as a prodrug to it in vivo.[1][2] The chemical structure of estradiol 3-propionate is contained within estradiol dipropionate, estrapronicate, and orestrate, all of which are also estradiol esters.[2]

See also


  1. 1 2 3 Woolfson AD, Elliott GR, Gilligan CA, Passmore CM (1999). "Design of an intravaginal ring for the controlled delivery of 17 beta-estradiol as its 3-acetate ester". J Control Release. 61 (3): 319–28. PMID 10477804.
  2. 1 2 3 J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. p. 898. ISBN 978-1-4757-2085-3.

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