Estradiol dipropionate

Estradiol dipropionate
Clinical data
Trade names Agofollin, Di-Ovocyclin, Progynon DP
Routes of
ATC code None
Legal status
Legal status
  • ℞ (Prescription only)
Synonyms 17β-Estradiol-3,17-dipropionate; Estra-1,3,5(10)-triene-3,17β-diol, 3,17β-dipropanoate
CAS Number 113-38-2
PubChem (CID) 8225
ChemSpider 7932
Chemical and physical data
Formula C24H32O4
Molar mass 384.509 g/mol
3D model (Jmol) Interactive image

Estradiol dipropionate (BAN, JAN) (brand names Agofollin, Di-Ovocyclin, Progynon DP, others) is a semisynthetic, steroidal estrogen that is or has been marketed in the United States and Europe.[1][2] It is the 3,17β-dipropanoyl ester of estradiol.[1][2] Along with estradiol benzoate, estradiol dipropionate was one of the first estradiol esters to be developed, having been patented in 1937,[3] was assessed in clinical studies by 1939,[4] and has been marketed by Schering as Progynon DP and Ciba Pharmaceutical Products as Di-Ovocylin since at least 1940.[5][6] Relative to estradiol benzoate, estradiol dipropionate has enhanced and very prolonged effects.[4] Prior to the development and introduction of estradiol valerate and estradiol cypionate in the 1950s, estradiol dipropionate and estradiol benzoate were the most widely used estradiol esters.[7]

See also


  1. 1 2 A. D. Roberts (1991). Dictionary of Steroids: Chemical Data, Structures, and Bibliographies. CRC Press. p. 415. ISBN 978-0-412-27060-4. Retrieved 20 May 2012.
  2. 1 2 Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. pp. 406–. ISBN 978-3-88763-075-1.
  3. States2233025 United States 2233025, Karl Miescher, Riehen, & Caesar Scholz, "Estradiol-17-monoesters", published 1941-02-25, assigned to Ciba Pharmaceutical Products, Inc.
  4. 1 2 Greene, R. R.; Dorr, E. M. (1939). "CLINICAL USE OF A NEW ESTROGEN". Endocrinology. 24 (4): 577–578. doi:10.1210/endo-24-4-577. ISSN 0013-7227.
  5. Escamilla, Roberto F.; Lisserf, H. (1940). "INDUCTION OF MENARCHE AND DEVELOPMENT OF SECONDARY SEXUAL CHARACTERISTICS IN A WOMAN AGED 34 BY INJECTIONS OF ESTRADIOL DIPROPIONATE*". Endocrinology. 27 (1): 153–153. doi:10.1210/endo-27-1-153. ISSN 0013-7227. The estradiol dipropionate used in this case was furnished by the Ciba Co. Their trade name for this product is Di-Ovocylin.
  6. Shorr, E. (1940). "Effect of Concomitant Administration of Estroens and Proesterone on Vainal Smear in Man.". Experimental Biology and Medicine. 43 (3): 501–506. doi:10.3181/00379727-43-11244. ISSN 1535-3702. Grateful acknowledgment is made to Dr. Erwin Schwenk of the Schering Corporation for the estradiol benzoate (Progynon B), estradiol dipropionate (Progynon DP), progesterone (Proluton), and pregneninolone (Pranone) used in these experiments;
  7. SCHWARTZ MM, SOULE SD (1955). "Estradiol 17-beta-cyclopentylpropionate, a longacting estrogen". Am. J. Obstet. Gynecol. 70 (1): 44–50. PMID 14388061.

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