CAS Number 39791-20-3
PubChem (CID) 38346
ChemSpider 35146
KEGG D05212
Chemical and physical data
Formula C25H32O3
Molar mass 380.51978 g/mol
3D model (Jmol) Interactive image

Nilestriol (INN) (brand name Wei Ni An; developmental code name LY-49825), also known as nylestriol (USAN, BAN), is a synthetic, steroidal estrogen that was patented in 1971[1] and is marketed in China.[2][3] It is the 3-cyclopentyl ether of ethinyl estriol, and is also known as ethinyl estriol cyclopentyl ether (EE3CPE).[4] Nilestriol is a prodrug of ethinyl estriol, and is a more potent estrogen in comparison.[4] It is described as a slowly-metabolized, long-acting estrogen and derivative of estriol.[5][6] Nilestriol was assessed in combination with levonorgestrel for the potential treatment of postmenopausal osteoporosis, but this formulation ultimately was not marketed.[7]

See also


  1. Official Gazette of the United States Patent and Trademark Office: Patents. U.S. Department of Commerce, Patent and Trademark Office. 1975. p. 1677.
  2. J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 891–. ISBN 978-1-4757-2085-3.
  4. 1 2 William McGuire (14 December 2013). Experimental Biology. Springer Science & Business Media. pp. 161–. ISBN 978-1-4757-4673-0.
  5. Daniel Robert Schoenberg (1977). Biochemical Properties of the Cytoplasmic Estrogen Receptors from Immature Rat and Mature Rabbit Uteri. University of Wisconsin. p. A-17.
  6. Excerpta medica. Section 10: Obstetrics and gynecology. 1978.
  7. Jeffrey K. Aronson (21 February 2009). Meyler's Side Effects of Endocrine and Metabolic Drugs. Elsevier. pp. 173–. ISBN 978-0-08-093292-7.

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