A progonadotropin or hypergonadotropin is a type of drug which increases the secretion of one or both of the major gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This, in turn, results in increased function and maintenance of the gonads and increased gonadal steroidogenesis of sex hormones such as androgens, estrogens, and progestogens. Progonadotropins are the functional opposites of antigonadotropins. They have clinical applications in the treatment of hypogonadism and infertility. Alternatively, hypergonadotropic effects may occur as a side effect of some drugs. Examples of progonadotropic drugs include gonadotropin-releasing hormone (GnRH) agonists administered in a pulsatile fashion, antiestrogens such as tamoxifen, clomifene, and aromatase inhibitors like anastrozole in both men and women, and pure antiandrogens such as flutamide, bicalutamide, and enzalutamide exclusively in men.
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