"Ogen" redirects here. For the character in the Japanese anime, see Ogen (Basilisk).
Clinical data
AHFS/ Monograph
ATC code none
CAS Number 7280-37-7 N
PubChem (CID) 5284555
DrugBank DB04574 YesY
ChemSpider 4447610 YesY
KEGG D00948 YesY
Chemical and physical data
Formula C22H32N2O5S
Molar mass 436.56 g/mol
3D model (Jmol) Interactive image
 NYesY (what is this?)  (verify)

Estropipate (INN, USAN, BAN) (brand names Harmogen, Improvera, Ogen, Ortho-Est, many others), also known as piperazine estrone sulfate, is a semi-synthetic, steroidal estrogen that is used mainly in hormone replacement therapy in the treatment of symptoms of menopause.[1][2] It is a salt of estrone sulfate and piperazine, and is hydrolyzed into estrone in the body.[1][2]


Estropipate is used to:


Estropipate is an agonist of the estrogen receptor (ER). In addition, estropipate has been found to act as an inhibitor of SLCO1B1 (OATP1B1) (IC50 = 70 nM).

See also


  1. 1 2 J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 900–. ISBN 978-1-4757-2085-3.
  2. 1 2 I.K. Morton; Judith M. Hall (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer Science & Business Media. pp. 114–. ISBN 978-94-011-4439-1.
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