Clinical data
Routes of
CAS Number 474-87-3
PubChem (CID) 6451472
ChemSpider 4953937
Chemical and physical data
Formula C18H20O2
Molar mass 268.3502 g/mol
3D model (Jmol) Interactive image

8,9-Dehydroestrone, or Δ8-estrone, also known as estra-1,3,5(10),8-tetraen-3-ol-17-one, is a naturally occurring steroidal estrogen found in horses that is closely related to equilin, equilenin, and estrone, and, as the 3-sulfate ester sodium salt, is a minor constituent (3.5%) of conjugated equine estrogens (Premarin).[1] It produces 8,9-dehydroestradiol as an important active metabolite, analogously to conversion of estrone or estrone sulfate into estradiol.[2]

See also


  1. Marc A. Fritz; Leon Speroff (28 March 2012). Clinical Gynecologic Endocrinology and Infertility. Lippincott Williams & Wilkins. pp. 751–. ISBN 978-1-4511-4847-3.
  2. Kuhl H (2005). "Pharmacology of estrogens and progestogens: influence of different routes of administration". Climacteric. 8 Suppl 1: 3–63. doi:10.1080/13697130500148875. PMID 16112947.

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