ZEB1

ZEB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E19
Identifiers
Aliases	ZEB1, zinc finger E-box binding homeobox 1, AREB6, BZP, DELTAEF1, FECD6, NIL2A, PPCD3, TCF8, ZFHEP, ZFHX1A
External IDs	MGI: 1344313 HomoloGene: 31779 GeneCards: ZEB1
Gene ontology Molecular function • DNA binding • transcription corepressor activity • transcription coactivator activity • zinc ion binding • transcription factor binding • chromatin binding • metal ion binding • protein binding • nucleic acid binding • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding • transcription factor activity, sequence-specific DNA binding • E-box binding Cellular component • cytoplasm • transcription factor complex • nucleoplasm • nucleus Biological process • pattern specification process • embryonic skeletal system morphogenesis • regulation of smooth muscle cell differentiation • animal organ development • cell differentiation • semicircular canal morphogenesis • regulation of transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • nervous system development • regulation of transforming growth factor beta receptor signaling pathway • regulation of T cell differentiation in thymus • central nervous system development • cartilage development • regulation of mesenchymal cell proliferation • embryonic camera-type eye morphogenesis • cochlea morphogenesis • immune response • embryonic morphogenesis • cellular response to amino acid stimulus • cell proliferation • negative regulation of epithelial cell differentiation • positive regulation of transcription from RNA polymerase II promoter • negative regulation of cell proliferation • negative regulation of transcription, DNA-templated • positive regulation of neuron differentiation • negative regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6935	21417
Ensembl	ENSG00000148516	ENSMUSG00000024238
UniProt	P37275	Q64318
RefSeq (mRNA)	NM_001128128 NM_001174093 NM_001174094 NM_001174095 NM_001174096 NM_030751 NM_001323638 NM_001323641 NM_001323642 NM_001323643 NM_001323644 NM_001323645 NM_001323646 NM_001323647 NM_001323648 NM_001323649 NM_001323650 NM_001323651 NM_001323652 NM_001323653 NM_001323654 NM_001323655 NM_001323656 NM_001323657 NM_001323658 NM_001323659 NM_001323660 NM_001323661 NM_001323662 NM_001323663 NM_001323664 NM_001323665 NM_001323666 NM_001323671 NM_001323672 NM_001323673 NM_001323674 NM_001323675 NM_001323676 NM_001323677 NM_001323678	NM_011546
RefSeq (protein)	NP_001121600.1 NP_001167564.1 NP_001167565.1 NP_001167566.1 NP_001167567.1 NP_110378.3	NP_035676.1
Location (UCSC)	Chr 10: 31.32 – 31.53 Mb	Chr 18: 5.59 – 5.78 Mb
PubMed search	[1]	[2]
Wikidata

Zinc finger E-box-binding homeobox 1 is a protein that in humans is encoded by the ZEB1 gene.^[3][4][5]

ZEB1 (previously known as TCF8) encodes a zinc finger and homeodomain transcription factor that represses T-lymphocyte-specific IL2 gene expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site.^[5][6] ZEB1 and its mammalian paralog ZEB2 belongs to the Zeb family within the ZF (zinc finger) class of homeodomain transcription factors. ZEB1 protein has 7 zinc fingers and 1 homeodomain.^[7] The structure of the homeodomain shown on the right.

Clinical significance

Mutations of the gene are linked to posterior polymorphous corneal dystrophy 3. A recent study suggested its contributing role in lung cancer invasiveness and metastasis development.^[8]

References

Further reading

External links

• FactorBook ZEB1

PDB gallery
2e19: Solution structure of the homeobox domain from human NIL-2-A zinc finger protein, transcription factor 8