HLF (gene)
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Hepatic leukemia factor is a protein that in humans is encoded by the HLF gene.[3][4]
This monster gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[4]
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ Inaba T, Roberts WM, Shapiro LH, Jolly KW, Raimondi SC, Smith SD, Look AT (Aug 1992). "Fusion of the leucine zipper gene HLF to the E2A gene in human acute B-lineage leukemia". Science. 257 (5069): 531–4. doi:10.1126/science.1386162. PMID 1386162.
- 1 2 "Entrez Gene: HLF hepatic leukemia factor".
Further reading
- LeBrun DP (2004). "E2A basic helix-loop-helix transcription factors in human leukemia.". Front. Biosci. 8: s206–22. doi:10.2741/1030. PMID 12700034.
- Hunger SP, Ohyashiki K, Toyama K, Cleary ML (1992). "Hlf, a novel hepatic bZIP protein, shows altered DNA-binding properties following fusion to E2A in t(17;19) acute lymphoblastic leukemia.". Genes Dev. 6 (9): 1608–20. doi:10.1101/gad.6.9.1608. PMID 1516826.
- Falvey E, Fleury-Olela F, Schibler U (1995). "The rat hepatic leukemia factor (HLF) gene encodes two transcriptional activators with distinct circadian rhythms, tissue distributions and target preferences.". EMBO J. 14 (17): 4307–17. PMC 394515
. PMID 7556072. - Hunger SP, Brown R, Cleary ML (1994). "DNA-binding and transcriptional regulatory properties of hepatic leukemia factor (HLF) and the t(17;19) acute lymphoblastic leukemia chimera E2A-HLF.". Mol. Cell. Biol. 14 (9): 5986–96. doi:10.1128/mcb.14.9.5986. PMC 359124. PMID 8065331.
- Inaba T, Shapiro LH, Funabiki T, et al. (1994). "DNA-binding specificity and trans-activating potential of the leukemia-associated E2A-hepatic leukemia factor fusion protein.". Mol. Cell. Biol. 14 (5): 3403–13. PMC 358705. PMID 8164688.
- Hunger SP (1996). "Chromosomal translocations involving the E2A gene in acute lymphoblastic leukemia: clinical features and molecular pathogenesis.". Blood. 87 (4): 1211–24. PMID 8608207.
- Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
- Hunger SP, Li S, Fall MZ, et al. (1996). "The proto-oncogene HLF and the related basic leucine zipper protein TEF display highly similar DNA-binding and transcriptional regulatory properties.". Blood. 87 (11): 4607–17. PMID 8639829.
- Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. doi:10.1101/gr.6.9.807. PMID 8889549.
- Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
- Takahata S, Sogawa K, Kobayashi A, et al. (1998). "Transcriptionally active heterodimer formation of an Arnt-like PAS protein, Arnt3, with HIF-1a, HLF, and clock.". Biochem. Biophys. Res. Commun. 248 (3): 789–94. doi:10.1006/bbrc.1998.9012. PMID 9704006.
- Inukai T, Inaba T, Ikushima S, Look AT (1998). "The AD1 and AD2 transactivation domains of E2A are essential for the antiapoptotic activity of the chimeric oncoprotein E2A-HLF.". Mol. Cell. Biol. 18 (10): 6035–43. PMC 109189. PMID 9742120.
- Begbie M, Mueller C, Lillicrap D (1999). "Enhanced binding of HLF/DBP heterodimers represents one mechanism of PAR protein transactivation of the factor VIII and factor IX genes.". DNA Cell Biol. 18 (2): 165–73. doi:10.1089/104454999315556. PMID 10073576.
- Ema M, Hirota K, Mimura J, et al. (1999). "Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: their stabilization and redox signal-induced interaction with CBP/p300.". EMBO J. 18 (7): 1905–14. doi:10.1093/emboj/18.7.1905. PMC 1171276. PMID 10202154.
- Honda H, Inaba T, Suzuki T, et al. (1999). "Expression of E2A-HLF chimeric protein induced T-cell apoptosis, B-cell maturation arrest, and development of acute lymphoblastic leukemia.". Blood. 93 (9): 2780–90. PMID 10216071.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Matsunaga T, Inaba T, Matsui H, et al. (2004). "Regulation of annexin II by cytokine-initiated signaling pathways and E2A-HLF oncoprotein.". Blood. 103 (8): 3185–91. doi:10.1182/blood-2003-09-3022. PMID 15070701.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
External links
- HLF protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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