Aliases HES5, bHLHb38, hes family bHLH transcription factor 5
External IDs MGI: 104876 HomoloGene: 7755 GeneCards: HES5
Species Human Mouse









RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 1: 2.53 – 2.53 Mb Chr 4: 154.96 – 154.96 Mb
PubMed search [1] [2]
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Transcription factor HES-5 is a protein that in humans is encoded by the HES5 gene.[3][4]

HES5 regulates brain development process.[5] HES5 expression significantly higher in squamous cervical carcinoma than in CIN as well as higher in CIN than normal cervical epithelia.[6] Human HES5 gene binds to Notch receptor and expression of HES5 decreases during cartilage differentiation.[7]


  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Takebayashi K, Akazawa C, Nakanishi S, Kageyama R (Feb 1995). "Structure and promoter analysis of the gene encoding the mouse helix-loop-helix factor HES-5. Identification of the neural precursor cell-specific promoter element". J Biol Chem. 270 (3): 1342–9. doi:10.1074/jbc.270.3.1342. PMID 7836401.
  4. "Entrez Gene: HES5 hairy and enhancer of split 5 (Drosophila)".
  5. Hatakeyama J, Bessho Y, Katoh K, Ookawara S, Fujioka M, Guillemot F, Kageyama R (November 2004). "Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation". Development. 131 (22): 5539–50. doi:10.1242/dev.01436. PMID 15496443.
  6. Liu J, Ye F, Chen H, Lü W, Zhou C, Xie X (2007). "Expression of differentiation associated protein Hes1 and Hes5 in cervical squamous carcinoma and its precursors". Int. J. Gynecol. Cancer. 17 (6): 1293–9. doi:10.1111/j.1525-1438.2007.00930.x. PMID 17388915.
  7. Karlsson C, Jonsson M, Asp J, Brantsing C, Kageyama R, Lindahl A (March 2007). "Notch and HES5 are regulated during human cartilage differentiation". Cell Tissue Res. 327 (3): 539–51. doi:10.1007/s00441-006-0307-0. PMID 17093926.

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241Freely accessible. PMID 12477932. 
  • Gazit R, Krizhanovsky V, Ben-Arie N (2004). "Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway.". Development. 131 (4): 903–13. doi:10.1242/dev.00982. PMID 14757642. 
  • Nakatani T, Mizuhara E, Minaki Y, et al. (2004). "Helt, a novel basic-helix-loop-helix transcriptional repressor expressed in the developing central nervous system.". J. Biol. Chem. 279 (16): 16356–67. doi:10.1074/jbc.M311740200. PMID 14764602. 
  • Kamakura S, Oishi K, Yoshimatsu T, et al. (2004). "Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling.". Nat. Cell Biol. 6 (6): 547–54. doi:10.1038/ncb1138. PMID 15156153. 
  • Katoh M, Katoh M (2005). "Identification and characterization of human HES2, HES3, and HES5 genes in silico.". Int. J. Oncol. 25 (2): 529–34. doi:10.3892/ijo.25.2.529. PMID 15254753. 
  • Ohtsuka T, Imayoshi I, Shimojo H, et al. (2006). "Visualization of embryonic neural stem cells using Hes promoters in transgenic mice.". Mol. Cell. Neurosci. 31 (1): 109–22. doi:10.1016/j.mcn.2005.09.006. PMID 16214363. 
  • Ong CT, Cheng HT, Chang LW, et al. (2006). "Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability.". J. Biol. Chem. 281 (8): 5106–19. doi:10.1074/jbc.M506108200. PMID 16365048. 
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature. 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414. 
  • Karlsson C, Brantsing C, Svensson T, et al. (2007). "Differentiation of human mesenchymal stem cells and articular chondrocytes: analysis of chondrogenic potential and expression pattern of differentiation-related transcription factors.". J. Orthop. Res. 25 (2): 152–63. doi:10.1002/jor.20287. PMID 17072841. 
  • Karlsson C, Jonsson M, Asp J, et al. (2007). "Notch and HES5 are regulated during human cartilage differentiation.". Cell Tissue Res. 327 (3): 539–51. doi:10.1007/s00441-006-0307-0. PMID 17093926. 

External links

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