Aliases POU4F2, BRN3.2, BRN3B, Brn-3b, POU class 4 homeobox 2
External IDs MGI: 102524 HomoloGene: 20959 GeneCards: POU4F2
RNA expression pattern
More reference expression data
Species Human Mouse









RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 4: 146.64 – 146.64 Mb Chr 8: 78.43 – 78.44 Mb
PubMed search [1] [2]
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POU domain, class 4, transcription factor 2 is a protein that in humans is encoded by the POU4F2 gene.[3][4]


POU4F2 is a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. A class IV POU-domain protein, POU4F2 is found in human retina exclusively within a subpopulation of ganglion cells where it may play a role in determining or maintaining the identities of a small subset of visual system neurons.[supplied by OMIM][4]


POU4F2 has been shown to interact with Estrogen receptor alpha.[5]

See also


Further reading

  • Xiang M, Zhou L, Macke JP, Yoshioka T, Hendry SH, Eddy RL, Shows TB, Nathans J (Jul 1995). "The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons". The Journal of Neuroscience. 15 (7 Pt 1): 4762–85. PMID 7623109. 
  • Xiang M, Zhou L, Peng YW, Eddy RL, Shows TB, Nathans J (Oct 1993). "Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells". Neuron. 11 (4): 689–701. doi:10.1016/0896-6273(93)90079-7. PMID 7691107. 
  • Bhargava AK, Li Z, Weissman SM (Nov 1993). "Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells". Proceedings of the National Academy of Sciences of the United States of America. 90 (21): 10260–4. doi:10.1073/pnas.90.21.10260. PMC 47754Freely accessible. PMID 8234287. 
  • Smith MD, Dawson SJ, Latchman DS (Jan 1997). "Inhibition of neuronal process outgrowth and neuronal specific gene activation by the Brn-3b transcription factor". The Journal of Biological Chemistry. 272 (2): 1382–8. doi:10.1074/jbc.272.2.1382. PMID 8995448. 
  • Budhram-Mahadeo V, Parker M, Latchman DS (Feb 1998). "POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element". Molecular and Cellular Biology. 18 (2): 1029–41. doi:10.1128/mcb.18.2.1029. PMC 108815Freely accessible. PMID 9448000. 
  • Dennis JH, Budhram-Mahadeo V, Latchman DS (Aug 2001). "The Brn-3b POU family transcription factor regulates the cellular growth, proliferation, and anchorage dependence of MCF7 human breast cancer cells". Oncogene. 20 (36): 4961–71. doi:10.1038/sj.onc.1204491. PMID 11526481. 
  • de Melo J, Qiu X, Du G, Cristante L, Eisenstat DD (Jun 2003). "Dlx1, Dlx2, Pax6, Brn3b, and Chx10 homeobox gene expression defines the retinal ganglion and inner nuclear layers of the developing and adult mouse retina". The Journal of Comparative Neurology. 461 (2): 187–204. doi:10.1002/cne.10674. PMID 12724837. 
  • Samady L, Dennis J, Budhram-Mahadeo V, Latchman DS (Mar 2004). "Activation of CDK4 gene expression in human breast cancer cells by the Brn-3b POU family transcription factor". Cancer Biology & Therapy. 3 (3): 317–23. doi:10.4161/cbt.3.3.698. PMID 14726699. 
  • Irshad S, Pedley RB, Anderson J, Latchman DS, Budhram-Mahadeo V (May 2004). "The Brn-3b transcription factor regulates the growth, behavior, and invasiveness of human neuroblastoma cells in vitro and in vivo". The Journal of Biological Chemistry. 279 (20): 21617–27. doi:10.1074/jbc.M312506200. PMID 14970234. 
  • Lee SA, Ndisang D, Patel C, Dennis JH, Faulkes DJ, D'Arrigo C, Samady L, Farooqui-Kabir S, Heads RJ, Latchman DS, Budhram-Mahadeo VS (Apr 2005). "Expression of the Brn-3b transcription factor correlates with expression of HSP-27 in breast cancer biopsies and is required for maximal activation of the HSP-27 promoter". Cancer Research. 65 (8): 3072–80. doi:10.1158/0008-5472.CAN-04-2865. PMID 15833836. 
  • Weishaupt JH, Klöcker N, Bähr M (2005). "Axotomy-induced early down-regulation of POU-IV class transcription factors Brn-3a and Brn-3b in retinal ganglion cells". Journal of Molecular Neuroscience. 26 (1): 17–25. doi:10.1385/JMN:26:1:017. PMID 15968082. 
  • Samady L, Faulkes DJ, Budhram-Mahadeo V, Ndisang D, Potter E, Brabant G, Latchman DS (Feb 2006). "The Brn-3b POU family transcription factor represses plakoglobin gene expression in human breast cancer cells". International Journal of Cancer. Journal International Du Cancer. 118 (4): 869–78. doi:10.1002/ijc.21435. PMID 16152597. 
  • Choy KW, Wang CC, Ogura A, Lau TK, Rogers MS, Ikeo K, Gojobori T, Lam DS, Pang CP (Mar 2006). "Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes". Physiological Genomics. 25 (1): 9–15. doi:10.1152/physiolgenomics.00121.2005. PMID 16368877. 
  • Calissano M, Diss JK, Latchman DS (May 2007). "Post-transcriptional regulation of the Brn-3b transcription factor in differentiating neuroblastoma cells". FEBS Letters. 581 (13): 2490–6. doi:10.1016/j.febslet.2007.04.066. PMID 17490655. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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