Pax genes

Paired box (Pax) genes are a family of genes coding for tissue specific transcription factors containing a paired domain and usually a partial, or in the case of four family members (PAX3, PAX4, PAX6 and PAX7),[1] a complete homeodomain. An octapeptide may also be present. Pax proteins are important in early animal development for the specification of specific tissues, as well as during epimorphic limb regeneration in animals capable of such.


Within the mammalian family, there are four well defined groups of Pax genes.

Orthologous genes exist throughout the Metazoa, including extensive study of the ectopic expression in Drosophila using murine Pax6.


See also


  1. Chi, N; Epstein, JA (January 2002). "Getting your Pax straight: Pax proteins in development and disease.". Trends in genetics : TIG. 18 (1): 41–7. doi:10.1016/s0168-9525(01)02594-x. PMID 11750700.
  2. Online Mendelian Inheritance in Man (OMIM) 167409
  3. Medic S, Ziman M (April 2010). Soyer, H. Peter, ed. "PAX3 Expression in Normal Skin Melanocytes and Melanocytic Lesions (Naevi and Melanomas)". PLoS ONE. 5 (4): e9977. doi:10.1371/journal.pone.0009977. PMC 2858648Freely accessible. PMID 20421967.
  4. Scholl FA, Kamarashev J, Murmann OV, Geertsen R, Dummer R, Schäfer BW (Feb 2001). "PAX3 is expressed in human melanomas and contributes to tumor cell survival". Cancer Res. 61 (3): 823–6. PMID 11221862.
  5. Oustanina, S; et al. (2004). "PAX7 directs postnatal renewal and propagation of myogenic satellite cells but not their specification". The EMBO Journal. 23: 3430–3439. doi:10.1038/sj.emboj.7600346.

Further reading

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