KLF13
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Kruppel-like factor 13, also known as KLF13, is a protein that in humans is encoded by the KLF13 gene.[3][4][5]
Function
KLF13 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes.[3][6]
KLF13 was first described as the RANTES factor of late activated T lymphocytes (RFLAT)-1.[5] It regulates the expression of the chemokine RANTES in T lymphocytes. It functions as a lynchpin, inducing a large enhancesome. KLF13 knock-out mice show a defect in lymphocyte survival as KLF13 is a regulator of Bcl-xL expression.[5][7][8][9][10][11][12]
Interactions
KLF13 has been shown to interact with CREB-binding protein,[13] Heat shock protein 47[13] and PCAF.[13]
See also
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- 1 2 "Entrez Gene: KLF13 Kruppel-like factor 13".
- ↑ Cook T, Gebelein B, Urrutia R (Jun 1999). "Sp1 and its likes: biochemical and functional predictions for a growing family of zinc finger transcription factors". Annals of the New York Academy of Sciences. 880 (1 CELL AND MOLE): 94–102. doi:10.1111/j.1749-6632.1999.tb09513.x. PMID 10415854.
- 1 2 3 Song A, Chen YF, Thamatrakoln K, Storm TA, Krensky AM (Jan 1999). "RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes". Immunity. 10 (1): 93–103. doi:10.1016/S1074-7613(00)80010-2. PMID 10023774.
- ↑ Scohy S, Gabant P, Van Reeth T, Hertveldt V, Drèze PL, Van Vooren P, Rivière M, Szpirer J, Szpirer C (Nov 2000). "Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family". Genomics. 70 (1): 93–101. doi:10.1006/geno.2000.6362. PMID 11087666.
- ↑ Song A, Nikolcheva T, Krensky AM (Oct 2000). "Transcriptional regulation of RANTES expression in T lymphocytes". Immunological Reviews. 177 (1): 236–45. doi:10.1034/j.1600-065X.2000.17610.x. PMID 11138780.
- ↑ Nikolcheva T, Pyronnet S, Chou SY, Sonenberg N, Song A, Clayberger C, Krensky AM (Jul 2002). "A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes". The Journal of Clinical Investigation. 110 (1): 119–26. doi:10.1172/JCI15336. PMC 151028
. PMID 12093895. - ↑ Song A, Patel A, Thamatrakoln K, Liu C, Feng D, Clayberger C, Krensky AM (Aug 2002). "Functional domains and DNA-binding sequences of RFLAT-1/KLF13, a Krüppel-like transcription factor of activated T lymphocytes". The Journal of Biological Chemistry. 277 (33): 30055–65. doi:10.1074/jbc.M204278200. PMID 12050170.
- ↑ Zhou M, McPherson L, Feng D, Song A, Dong C, Lyu SC, Zhou L, Shi X, Ahn YT, Wang D, Clayberger C, Krensky AM (May 2007). "Kruppel-like transcription factor 13 regulates T lymphocyte survival in vivo". Journal of Immunology. 178 (9): 5496–504. doi:10.4049/jimmunol.178.9.5496. PMC 2664650. PMID 17442931.
- ↑ Huang B, Ahn YT, McPherson L, Clayberger C, Krensky AM (Jun 2007). "Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription". Journal of Immunology. 178 (11): 7081–7. doi:10.4049/jimmunol.178.11.7081. PMC 2674583. PMID 17513757.
- ↑ Ahn YT, Huang B, McPherson L, Clayberger C, Krensky AM (Jan 2007). "Dynamic interplay of transcriptional machinery and chromatin regulates "late" expression of the chemokine RANTES in T lymphocytes". Molecular and Cellular Biology. 27 (1): 253–66. doi:10.1128/MCB.01071-06. PMC 1800668. PMID 17074812.
- 1 2 3 Song CZ, Keller K, Murata K, Asano H, Stamatoyannopoulos G (Mar 2002). "Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2". The Journal of Biological Chemistry. 277 (9): 7029–36. doi:10.1074/jbc.M108826200. PMC 2808425. PMID 11748222.
Further reading
- Cook T, Gebelein B, Urrutia R (Jun 1999). "Sp1 and its likes: biochemical and functional predictions for a growing family of zinc finger transcription factors". Annals of the New York Academy of Sciences. 880 (1 CELL AND MOLE): 94–102. doi:10.1111/j.1749-6632.1999.tb09513.x. PMID 10415854.
- Song A, Chen YF, Thamatrakoln K, Storm TA, Krensky AM (Jan 1999). "RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes". Immunity. 10 (1): 93–103. doi:10.1016/S1074-7613(00)80010-2. PMID 10023774.
- Asano H, Li XS, Stamatoyannopoulos G (Jun 2000). "FKLF-2: a novel Krüppel-like transcriptional factor that activates globin and other erythroid lineage genes". Blood. 95 (11): 3578–84. PMID 10828046.
- Scohy S, Gabant P, Van Reeth T, Hertveldt V, Drèze PL, Van Vooren P, Rivière M, Szpirer J, Szpirer C (Nov 2000). "Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family". Genomics. 70 (1): 93–101. doi:10.1006/geno.2000.6362. PMID 11087666.
- Kaczynski J, Zhang JS, Ellenrieder V, Conley A, Duenes T, Kester H, van Der Burg B, Urrutia R (Sep 2001). "The Sp1-like protein BTEB3 inhibits transcription via the basic transcription element box by interacting with mSin3A and HDAC-1 co-repressors and competing with Sp1". The Journal of Biological Chemistry. 276 (39): 36749–56. doi:10.1074/jbc.M105831200. PMID 11477107.
- Song CZ, Keller K, Murata K, Asano H, Stamatoyannopoulos G (Mar 2002). "Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2". The Journal of Biological Chemistry. 277 (9): 7029–36. doi:10.1074/jbc.M108826200. PMC 2808425. PMID 11748222.
- Kaczynski JA, Conley AA, Fernandez Zapico M, Delgado SM, Zhang JS, Urrutia R (Sep 2002). "Functional analysis of basic transcription element (BTE)-binding protein (BTEB) 3 and BTEB4, a novel Sp1-like protein, reveals a subfamily of transcriptional repressors for the BTE site of the cytochrome P4501A1 gene promoter". The Biochemical Journal. 366 (Pt 3): 873–82. doi:10.1042/BJ20020388. PMC 1222816. PMID 12036432.
- Song A, Patel A, Thamatrakoln K, Liu C, Feng D, Clayberger C, Krensky AM (Aug 2002). "Functional domains and DNA-binding sequences of RFLAT-1/KLF13, a Krüppel-like transcription factor of activated T lymphocytes". The Journal of Biological Chemistry. 277 (33): 30055–65. doi:10.1074/jbc.M204278200. PMID 12050170.
- Nikolcheva T, Pyronnet S, Chou SY, Sonenberg N, Song A, Clayberger C, Krensky AM (Jul 2002). "A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes". The Journal of Clinical Investigation. 110 (1): 119–26. doi:10.1172/JCI15336. PMC 151028. PMID 12093895.
- Mitsuma A, Asano H, Kinoshita T, Murate T, Saito H, Stamatoyannopoulos G, Naoe T (Feb 2005). "Transcriptional regulation of FKLF-2 (KLF13) gene in erythroid cells". Biochimica et Biophysica Acta. 1727 (2): 125–33. doi:10.1016/j.bbaexp.2004.12.007. PMC 2808416. PMID 15716005.
- Zhang P, Basu P, Redmond LC, Morris PE, Rupon JW, Ginder GD, Lloyd JA (2006). "A functional screen for Krüppel-like factors that regulate the human gamma-globin gene through the CACCC promoter element". Blood Cells, Molecules & Diseases. 35 (2): 227–35. doi:10.1016/j.bcmd.2005.04.009. PMID 16023392.
- Ahn YT, Huang B, McPherson L, Clayberger C, Krensky AM (Jan 2007). "Dynamic interplay of transcriptional machinery and chromatin regulates "late" expression of the chemokine RANTES in T lymphocytes". Molecular and Cellular Biology. 27 (1): 253–66. doi:10.1128/MCB.01071-06. PMC 1800668. PMID 17074812.
- Huang B, Ahn YT, McPherson L, Clayberger C, Krensky AM (Jun 2007). "Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription". Journal of Immunology. 178 (11): 7081–7. doi:10.4049/jimmunol.178.11.7081. PMC 2674583. PMID 17513757.
External links
- KLF13 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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