TLX

NR2E1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4XAJ
Identifiers
Aliases	NR2E1, TLL, TLX, XTLL, nuclear receptor subfamily 2 group E member 1
External IDs	OMIM: 603849 MGI: 1100526 HomoloGene: 37750 GeneCards: NR2E1
Gene ontology Molecular function • sequence-specific DNA binding • DNA binding • transcription factor activity, sequence-specific DNA binding • zinc ion binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • histone deacetylase binding • metal ion binding • steroid hormone receptor activity • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • enzyme binding Cellular component • nucleoplasm • nucleus Biological process • glial cell migration • cell fate commitment • negative regulation of astrocyte differentiation • regulation of transcription, DNA-templated • negative regulation of neuron differentiation • somatic stem cell population maintenance • dentate gyrus development • negative regulation of neural precursor cell proliferation • regulation of cellular component organization • extracellular matrix organization • negative regulation of apoptotic process • negative regulation of transcription from RNA polymerase II promoter • behavioral fear response • regulation of timing of neuron differentiation • transcription, DNA-templated • nervous system development • positive regulation of angiogenesis • anterior commissure morphogenesis • regulation of dendrite morphogenesis • positive regulation of neural precursor cell proliferation • multicellular organism development • brain development • positive regulation of cell cycle • amygdala development • retina development in camera-type eye • forebrain generation of neurons • layer formation in cerebral cortex • positive regulation of cell proliferation • cerebral cortex development • social behavior • cerebral cortex neuron differentiation • regulation of cell migration involved in sprouting angiogenesis • camera-type eye development • olfactory bulb development • transcription initiation from RNA polymerase II promoter • positive regulation of stem cell proliferation • aggressive behavior • visual perception • steroid hormone mediated signaling pathway • positive regulation of transcription from RNA polymerase II promoter • long-term synaptic potentiation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7101	21907
Ensembl	ENSG00000112333	ENSMUSG00000019803
UniProt	Q9Y466	Q64104
RefSeq (mRNA)	NM_001286102 NM_003269	NM_152229
RefSeq (protein)	NP_001273031.1 NP_003260.1	NP_689415.1
Location (UCSC)	Chr 6: 108.17 – 108.19 Mb	Chr 10: 42.56 – 42.58 Mb
PubMed search	[1]	[2]
Wikidata

Nuclear receptor TLX (homologue of the Drosophila tailless gene) also known as NR2E1 (Nuclear receptor subfamily 2 group E member 1) is a protein that in humans is encoded by the NR2E1 gene.^[3] TLX is a member of the nuclear receptor family of intracellular transcription factors.

Function

TLX regulates the expression of another nuclear receptor, RAR.^[4]

TLX also is essential for normal brain-eye coordination and appears to play a role in control of aggressive behavior.^[5]

Adult neural stem cells are nuclear receptor TLX-positive and TLX expression in these cells is crucial in maintaining their undifferentiated state.^[6] Furthermore, TLX regulates adult neural stem cell proliferation. Removal of TLX from the adult mouse brain resulted in a reduction of stem cell proliferation and spatial learning.^[7]

Tlx-positive cells of the subventricular zone of adult mouse brain are self-renewing stem cells. Mutation of the Tlx gene in adult mouse brain leads to complete loss of neurogenesis in the subventricular zone. Tlx is also required for transition from radial glial cells to astrocyte-like neural stem cells.^[8]

References

Further reading

External links

• NR2E1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)