TFAP4

TFAP4
Identifiers
Aliases	TFAP4, AP-4, bHLHc41, transcription factor AP-4 (activating enhancer binding protein 4)
External IDs	MGI: 103239 HomoloGene: 2424 GeneCards: TFAP4
Gene ontology Molecular function • sequence-specific DNA binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • protein homodimerization activity • protein dimerization activity • transcription coactivator activity • histone deacetylase binding • protein heterodimerization activity • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • protein binding • DNA binding • E-box binding • transcription regulatory region DNA binding Cellular component • transcriptional repressor complex • nucleus Biological process • negative regulation of cell proliferation • negative regulation of cyclin-dependent protein serine/threonine kinase activity • transcription, DNA-templated • negative regulation of gene expression • DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator • cellular response to dexamethasone stimulus • negative regulation of DNA binding • positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway • positive regulation of apoptotic process • positive regulation of transcription, DNA-templated • negative regulation by host of viral transcription • negative regulation of cell cycle arrest • regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • positive regulation by host of viral transcription • transcription from RNA polymerase II promoter • negative regulation of transcription, DNA-templated • protein complex assembly Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7023	83383
Ensembl	ENSG00000090447	ENSMUSG00000005718
UniProt	Q01664	n/a
RefSeq (mRNA)	NM_003223	NM_031182
RefSeq (protein)	NP_003214.1	n/a
Location (UCSC)	Chr 16: 4.26 – 4.27 Mb	Chr 16: 4.54 – 4.56 Mb
PubMed search	[1]	[2]
Wikidata

Transcription factor AP-4 (activating enhancer binding protein 4), also known as TFAP4, is a protein which in humans is encoded by the TFAP4 gene.^[3]

Function

Transcription factor AP4 is a member of the basic helix-loop-helix (bHLH) transcription factors, which bind to the E-box sequence in the promoters of their target genes. AP-4 has been shown to act both as a repressor and an activator for different target genes.

References

Further reading

External links

• TFAP4 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.