Testicular receptor

nuclear receptor subfamily 2, group C, member 1
Symbol NR2C1
Alt. symbols TR2
Entrez 7181
HUGO 7971
OMIM 601529
RefSeq NM_003297
UniProt P13056
Other data
Locus Chr. 12 q22
nuclear receptor subfamily 2, group C, member 2
Symbol NR2C2
Alt. symbols TR4
Entrez 7182
HUGO 7972
OMIM 601426
RefSeq NM_003298
UniProt P49116
Other data
Locus Chr. 3 p25

The testicular receptor proteins are members of the nuclear receptor family of intracellular transcription factors.[1] There are two forms of the receptor, TR2 and TR4, each encode by a separate gene (NR2C1 and NR2C2 respectively).[2][3][4]


  1. Lee YF, Lee HJ, Chang C (2002). "Recent advances in the TR2 and TR4 orphan receptors of the nuclear receptor superfamily". J. Steroid Biochem. Mol. Biol. 81 (4–5): 291–308. doi:10.1016/S0960-0760(02)00118-8. PMID 12361719.
  2. Chang C, Kokontis J, Acakpo-Satchivi L, Liao S, Takeda H, Chang Y (1989). "Molecular cloning of new human TR2 receptors: a class of steroid receptor with multiple ligand-binding domains". Biochem. Biophys. Res. Commun. 165 (2): 735–41. doi:10.1016/S0006-291X(89)80028-2. PMID 2597158.
  3. Yoshikawa T, DuPont BR, Leach RJ, Detera-Wadleigh SD (1996). "New variants of the human and rat nuclear hormone receptor, TR4: expression and chromosomal localization of the human gene". Genomics. 35 (2): 361–6. doi:10.1006/geno.1996.0368. PMID 8661150.
  4. Chang C, Da Silva SL, Ideta R, Lee Y, Yeh S, Burbach JP (1994). "Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily". Proc. Natl. Acad. Sci. U.S.A. 91 (13): 6040–4. doi:10.1073/pnas.91.13.6040. PMC 44133Freely accessible. PMID 8016112.

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