STAT6

STAT6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1OJ5, 4Y5W, 4Y5U
Identifiers
Aliases	STAT6, D12S1644, IL-4-STAT, STAT6B, STAT6C, signal transducer and activator of transcription 6
External IDs	OMIM: 601512 MGI: 103034 HomoloGene: 2373 GeneCards: STAT6
Genetically Related Diseases
eosinophilic esophagitis[1]
Gene ontology Molecular function • identical protein binding • sequence-specific DNA binding • RNA polymerase II core promoter sequence-specific DNA binding • protein phosphatase binding • DNA binding • protein binding • signal transducer activity • transcription factor activity, sequence-specific DNA binding Cellular component • nucleus • nucleoplasm • nuclear chromatin • cytosol • membrane raft • cytoplasm Biological process • regulation of transcription from RNA polymerase II promoter • T-helper 1 cell lineage commitment • regulation of cell proliferation • response to cytokine • interleukin-4-mediated signaling pathway • regulation of transcription, DNA-templated • cytokine-mediated signaling pathway • cellular response to hydrogen peroxide • mammary gland epithelial cell proliferation • cellular response to reactive nitrogen species • positive regulation of type I interferon production • positive regulation of transcription from RNA polymerase II promoter • positive regulation of isotype switching to IgE isotypes • mammary gland morphogenesis • negative regulation of type 2 immune response • negative regulation of transcription from RNA polymerase II promoter • signal transduction • transcription, DNA-templated Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6778	20852
Ensembl	ENSG00000166888	ENSMUSG00000002147
UniProt	P42226	P52633
RefSeq (mRNA)	NM_001178078 NM_001178079 NM_001178080 NM_001178081 NM_003153	NM_009284
RefSeq (protein)	NP_001171549.1 NP_001171550.1 NP_001171551.1 NP_003144.3	NP_033310.2
Location (UCSC)	Chr 12: 57.1 – 57.13 Mb	Chr 10: 127.64 – 127.66 Mb
PubMed search	[2]	[3]
Wikidata

Signal transducer and activator of transcription 6 (STAT6) is a human gene. The protein encoded by this gene is a member of the STAT family of transcription factors.^[4][5]

In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2), expression of cell surface markers, and class switch of immunoglobulins.^[6]

Interactions

STAT6 has been shown to interact with:

• CREB-binding protein,^[7][8]
• EP300,^[7]
• IRF4,^[9]
• NFKB1,^[10]
• Nuclear receptor coactivator 1,^[8][11] and
• SND1.^[12]

Pathology

• Gene fusion
  • Recurrent somatic fusions of the two genes, NGFI-A–binding protein 2 (NAB2) and STAT6, located at chromosomal region 12q13, have been identified in solitary fibrous tumors.^[13]
• Amplification
  • STAT6 is amplified in a subset of dedifferentiated liposarcoma.^[14]

See also

• Interleukin 4

References

Further reading

External links

• STAT6 Transcription Factor at the US National Library of Medicine Medical Subject Headings (MeSH)