Kinase insert domain receptor

Available structures
PDBOrtholog search: PDBe RCSB
Aliases KDR, CD309, FLK1, VEGFR, VEGFR2, Kinase insert domain receptor
External IDs MGI: 96683 HomoloGene: 55639 GeneCards: KDR
Targeted by Drug
axitinib, cabozantinib, cediranib, lenvatinib, linifanib, motesanib, nintedanib, pazopanib, regorafenib, semaxanib, sorafenib, sunitinib, tivozanib, vandetanib, vatalanib[1]
RNA expression pattern
More reference expression data
Species Human Mouse









RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 4: 55.08 – 55.13 Mb Chr 5: 75.93 – 75.98 Mb
PubMed search [2] [3]
View/Edit HumanView/Edit Mouse

Kinase insert domain receptor (KDR, a type III receptor tyrosine kinase) also known as vascular endothelial growth factor receptor 2 (VEGFR-2) is a VEGF receptor. KDR is the human gene encoding it. KDR has also been designated as CD309 (cluster of differentiation 309). KDR is also known as Flk1 (Fetal Liver Kinase 1).


Kinase insert domain receptor has been shown to interact with SHC2,[4] Annexin A5[5] and SHC1.[6][7]

See also

Further reading


  1. "Drugs that physically interact with Vascular endothelial growth factor receptor 2 view/edit references on wikidata".
  2. "Human PubMed Reference:".
  3. "Mouse PubMed Reference:".
  4. Warner, A J; Lopez-Dee J; Knight E L; Feramisco J R; Prigent S A (April 2000). "The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells". Biochem. J. England. 347 (Pt 2): 501–9. doi:10.1042/0264-6021:3470501. ISSN 0264-6021. PMC 1220983Freely accessible. PMID 10749680.
  5. Wen, Y; Edelman J L; Kang T; Sachs G (May 1999). "Lipocortin V may function as a signaling protein for vascular endothelial growth factor receptor-2/Flk-1". Biochem. Biophys. Res. Commun. UNITED STATES. 258 (3): 713–21. doi:10.1006/bbrc.1999.0678. ISSN 0006-291X. PMID 10329451.
  6. Zanetti, Adriana; Lampugnani Maria Grazia; Balconi Giovanna; Breviario Ferruccio; Corada Monica; Lanfrancone Luisa; Dejana Elisabetta (April 2002). "Vascular endothelial growth factor induces SHC association with vascular endothelial cadherin: a potential feedback mechanism to control vascular endothelial growth factor receptor-2 signaling". Arterioscler. Thromb. Vasc. Biol. United States. 22 (4): 617–22. doi:10.1161/01.ATV.0000012268.84961.AD. PMID 11950700.
  7. D'Angelo, G; Martini J F; Iiri T; Fantl W J; Martial J; Weiner R I (May 1999). "16K human prolactin inhibits vascular endothelial growth factor-induced activation of Ras in capillary endothelial cells". Mol. Endocrinol. UNITED STATES. 13 (5): 692–704. doi:10.1210/mend.13.5.0280. ISSN 0888-8809. PMID 10319320.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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