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The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-κB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor.
As a drug target
Varlilumab is an antibody that binds to CD27 and is an experimental cancer treatment.
- "Human PubMed Reference:".
- "Mouse PubMed Reference:".
- "Entrez Gene: CD27 CD27 molecule".
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- van Baarle D, Kostense S, van Oers MH, Hamann D, Miedema F (Dec 2002). "Failing immune control as a result of impaired CD8+ T-cell maturation: CD27 might provide a clue". Trends in Immunology. 23 (12): 586–91. doi:10.1016/S1471-4906(02)02326-8. PMID 12464570.
- Dörner T, Lipsky PE (2005). "Correlation of circulating CD27high plasma cells and disease activity in systemic lupus erythematosus". Lupus. 13 (5): 283–9. doi:10.1191/0961203304lu1014oa. PMID 15230280.