tumor necrosis factor receptor superfamily, member 1A
Alt. symbols CD120a, TNFR1
Entrez 7132
HUGO 11916
OMIM 191190
RefSeq NM_001065
UniProt P19438
Other data
Locus Chr. 12 p13.2
tumor necrosis factor receptor superfamily, member 1B
Alt. symbols CD120a, TNFR2
Entrez 7133
HUGO 11917
OMIM 191191
RefSeq NM_001066
UniProt P20333
Other data
Locus Chr. 1 p36.22

CD120 (Cluster of Differentiation 120) can refer to two members of the tumor necrosis factor receptor superfamily: tumor necrosis factor receptor 1 (TNFR1) and tumor necrosis factor receptor 2 (TNFR2).[1][2]

Receptor subtypes

There are two variants of the receptor, each encoded by a separate gene:

TNFR1 is the receptor type responsible for mediation of TNF-alpha induced sickness behavior,[3] and is involved in neurotoxic processes.[4] Elevated levels of TNFR1 has been found in severe mental disorders.[5]

Signaling pathway

Signaling pathway of TNF-R1. Dashed grey lines represent multiple steps

See also


  1. Locksley RM, Killeen N, Lenardo MJ (2001). "The TNF and TNF receptor superfamilies: integrating mammalian biology". Cell. 104 (4): 487–501. doi:10.1016/S0092-8674(01)00237-9. PMID 11239407.
  2. Hehlgans T, Pfeffer K (2005). "The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games". Immunology. 115 (1): 1–20. doi:10.1111/j.1365-2567.2005.02143.x. PMC 1782125Freely accessible. PMID 15819693.
  3. Palin K, Bluthé RM, McCusker RH, Levade T, Moos F, Dantzer R, Kelley KW (January 2009). "The type 1 TNF receptor and its associated adapter protein, FAN, are required for TNFalpha-induced sickness behavior". Psychopharmacology (Berl.). 201 (4): 549–56. doi:10.1007/s00213-008-1331-4. PMC 2711641Freely accessible. PMID 18825372.
  4. McCoy MK, Tansey MG (2008). "TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease". J Neuroinflammation. 5 (1): 45. doi:10.1186/1742-2094-5-45. PMC 2577641Freely accessible. PMID 18925972.
  5. Hope S, Melle I, Aukrust P, Steen NE, Birkenaes AB, Lorentzen S, Agartz I, Ueland T, Andreassen OA (November 2009). "Similar immune profile in bipolar disorder and schizophrenia: selective increase in soluble tumor necrosis factor receptor I and von Willebrand factor". Bipolar Disord. 11 (7): 726–34. doi:10.1111/j.1399-5618.2009.00757.x. PMID 19839997.

External links

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