Glycoprotein Ib

Glycoprotein Ib (GPIb), also known as CD42,[1] is a component of the GPIb-V-IX complex on platelets. The GPIb-V-IX complex binds von Willebrand factor, allowing platelet adhesion and platelet plug formation at sites of vascular injury.

It is deficient in the Bernard-Soulier syndrome. A gain-of-function mutation causes platelet-type von Willebrand's disease.[2]

Autoantibodies against Ib/IX can be produced in immune thrombocytopenic purpura.[3]

Components include GP1BA and GP1BB.

It complexes with Glycoprotein IX.


  1. Bode AP, Read MS, Reddick RL (February 1999). "Activation and adherence of lyophilized human platelets on canine vessel strips in the Baumgartner perfusion chamber". J. Lab. Clin. Med. 133 (2): 200–11. doi:10.1016/S0022-2143(99)90013-6. PMID 9989772.
  2. McPherson & Pincus: Henry's Clinical Diagnosis and Management by Laboratory Methods, 21st ed., pp. 760-2 (W.B. Saunders, 2006).
  3. McMillan R (October 2007). "The pathogenesis of chronic immune thrombocytopenic purpura". Semin. Hematol. 44 (4 Suppl 5): S3–S11. doi:10.1053/j.seminhematol.2007.11.002. PMID 18096470.

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