Angiopoietin receptor

tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Symbol TIE1
Alt. symbols TIE, JTK14
Entrez 7075
HUGO 11809
OMIM 600222
RefSeq NM_005424
UniProt P35590
Other data
EC number
Locus Chr. 1 p34-p33
TEK tyrosine kinase, endothelial
Symbol TEK
Alt. symbols TIE2, TIE-2, VMCM1, CD202b
Entrez 7010
HUGO 11724
OMIM 600221
RefSeq NM_000459
UniProt Q02763
Other data
Locus Chr. 9 p21

The angiopoietin receptors are receptors that bind angiopoietin.

TIE-1 and TIE-2 comprise the cell-surface receptors that bind and are activated by the angiopoietins, (Ang1, Ang2, Ang3, Ang4). The angiopoietins are protein growth factors required for the formation of blood vessels (angiogenesis).


The angiopoietins are protein growth factors that promote angiogenesis, the formation of blood vessels. There are now four identified angiopoietins: Ang1, Ang2, Ang3, Ang4. Ang1 and Ang4 function as agonistic or activating ligands for Tie2, whereas Ang2 and Ang3 behave as competitive antagonists. They function by binding their physiologic receptors, Tie-1 and Tie-2. These are receptor tyrosine kinases, so named because they mediate cell signals by inducing the phosphorylation of key tyrosines, thus initiating cell signalling. It is somewhat controversial which of the Tie receptors mediate functional signals downstream of Ang stimulation. But it is clear that at least Tie-2 is capable of physiologic activation as a result of binding the angiopoietins.

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