CD96 (Cluster of Differentiation 96) or Tactile (T cell activation, increased late expression) is a T cell-specific receptor and shares sequence similarity with CD226 (also known as DNAM-1).[1] The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein. The protein may play a role in the adhesive interactions of activated T and NK cells during the late phase of the immune response. It may also function in antigen presentation. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. CD96 is a transmembrane glycoprotein that has three extracellular immunoglobulin-like domains and is expressed by all resting human and mouse NK cells. CD96 main ligand is CD155. CD 96 has approximately 20% homology with CD226 and competed for binding to CD155 with CD226.[2]


  1. Fuchs, Anja; Colonna, M. (October 2006). "The role of NK cell recognition of nectin and nectin-like proteins in tumor immunosurveillance". Semin. Cancer Biol. 16 (5): 359–366. doi:10.1016/j.semcancer.2006.07.002. PMID 16904340.
  2. Smyth, Mark J.; Martinet, L. (March 2015). "Balancing natural killer cell activation through paired receptors". Nature Rev Immunology. 15 (4): 243–254. doi:10.1038/nri3799. Retrieved 25 March 2015.

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