CAS Number 1663564-42-8
Chemical and physical data
Formula C25H28N4OS
Molar mass 432.59 g·mol−1
3D model (Jmol) Interactive image

GAT100 is a negative allosteric modulator of the cannabinoid CB1 receptor.[1][2]

See also


  1. Pushkar M. Kulkarni; Abhijit R. Kulkarni; Anisha Korde; Ritesh B. Tichkule; Robert B. Laprairie; Eileen M. Denovan-Wright; Han Zhou∥; David R. Janero; Nikolai Zvonok; Alexandros Makriyannis; Maria G. Cascio; Roger G. Pertwee; Ganesh A. Thakur (January 2016). "Novel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid 1 Receptor Allosteric Site(s)". Journal of Medicinal Chemistry. 59 (1): 44–60. doi:10.1021/acs.jmedchem.5b01303. PMC 4716578Freely accessible. PMID 26529344.
  2. Robert B. Laprairie; Abhijit R. Kulkarni; Pushkar M. Kulkarni; Dow P. Hurst; Diane Lynch; Patricia H. Reggio; David R. Janero; Roger G. Pertwee; Lesley A. Stevenson; Melanie E. M. Kelly; Eileen M. Denovan-Wright; Ganesh A. Thakur (April 2016). "Mapping Cannabinoid 1 Receptor Allosteric Site(s): Critical Molecular Determinant and Signaling Profile of GAT100, a Novel, Potent, and Irreversibly Binding Probe.". ACS Chemical Neuroscience. doi:10.1021/acschemneuro.6b00041. PMID 27046127.

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