Legal status
Legal status
  • Class B (UK), illegal in Sweden
CAS Number 914458-20-1
ChemSpider 23277882
Chemical and physical data
Formula C27H27NO
Molar mass 381.51 g/mol
3D model (Jmol) Interactive image

JWH-147 is an analgesic drug used in scientific research, which acts as a cannabinoid agonist at both the CB1 and CB2 receptors. It is somewhat selective for the CB2 subtype, with a Ki of 11.0nM at CB1 vs 7.1nM at CB2.[1] It was discovered and named after Dr. John W. Huffman. JWH-147 was banned in Sweden on 1 October 2010 as a hazardous good harmful to health, after being identified as an ingredient in "herbal" synthetic cannabis products.[2][3]

See also


  1. Huffman JW, Padgett LW, Isherwood ML, Wiley JL, Martin BR. 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: New high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorganic & Medicinal Chemistry Letters 2006; 16:5432-5435.
  2. Swedish Code of Statutes Regulation (2010:1086).
  3. Swedish Code of Statutes Regulation (2010:1086). (pdf)

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