CAS Number 249888-50-4
PubChem (CID) 10091328
ChemSpider 8266865 YesY
Chemical and physical data
Formula C26H38O2
Molar mass 382.577 g/mol
3D model (Jmol) Interactive image

AM-855 (part of the AM cannabinoid series) is an analgesic drug which is a cannabinoid agonist. It is a derivative of Δ8Tetrahydrocannabinol with a conformationally restricted side chain which has been bound into a fourth ring fused to the aromatic A-ring of the cannabinoid skeleton. AM-855 is an agonist at both CB1 and CB2 with moderate selectivity for CB1, with a Ki of 22.3nM at CB1 and 58.6nM at CB2.[1]


  1. Khanolkara, Atmaram D.; Lua, Dai; Fana, Pusheng; Tiana, Xiaoyu; Makriyannis, Alexandros (August 1999). "Novel conformationally restricted tetracyclic analogs of Δ8-tetrahydrocannabinol". Bioorganic & Medicinal Chemistry Letters. 9 (15): 2119–24. doi:10.1016/S0960-894X(99)00355-8. PMID 10465529.

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