Maslinic acid

Maslinic acid
IUPAC name
(4aS,6aR,6aS,6bR,8aR,10R,11R,12aR,14bS)-10,11-dihydroxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
Systematic IUPAC name
(2α,3β)-2,3-Dihydroxyolean-12-en-28-oic acid
Other names
Crategolic acid; Masilinic acid; Crataegolic acid
4373-41-5 YesY
3D model (Jmol) Interactive image
ChemSpider 66312 N
ECHA InfoCard 100.128.873
KEGG C16939 N
PubChem 73659
Molar mass 472.71 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Maslinic acid is a compound derived from dry olive-pomace oil (an olive skin wax) which is a byproduct of olive oil extraction. It is a member of the group of triterpenes known as oleananes.


In vitro study shows that maslinic acid inhibits serine proteases, key enzymes necessary for the spread of HIV within an individual's body.[1] It also has in vitro antiproliferative effects on colon cancer cells.[2] Maslinic acid increases EAAT2 (GLT-1) glutamate reuptake and may reduce glutamatergic toxicity in rats.[3]


  1. "Compound From Olive-pomace Oil Inhibits HIV Spread". Retrieved 2009-06-16.
  2. Juan ME, et al. (2008). "Antiproliferative and apoptosis-inducing effects of maslinic and oleanolic acids, two pentacyclic triterpenes from olives, on HT-29 colon cancer cells". Br J Nutr. 100 (1): 36–43. doi:10.1017/S0007114508882979. PMID 18298868.
  3. Guan T, Qian Y, et al. (2011). "Maslinic acid, a natural inhibitor of glycogen phosphorylase, reduces cerebral ischemic injury in hyperglycemic rats by GLT-1 up-regulation". J. Neurosci. Res. 89 (11): 1829–39. doi:10.1002/jnr.22671. PMID 21800347.
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