AM-906
 | |
| Identifiers | |
|---|---|
| |
| CAS Number |
180989-26-8  |
| PubChem (CID) | 10089808 |
| ChemSpider |
8174103 |
| ChEMBL |
CHEMBL127848 |
| Chemical and physical data | |
| Formula | C23H34O3 |
| Molar mass | 358.513 g/mol |
| 3D model (Jmol) | Interactive image |
| |
| |
| (verify) | |
AM-906 (part of the AM cannabinoid series) is an analgesic drug which is a cannabinoid agonist. It is conformationally restricted by virtue of the double bond on its side chain, leading an increased affinity for and selectivity between CB1 and CB2 receptors.[1] It is a potent and selective agonist for the CB1 cannabinoid receptor, with a Ki of 0.8 nM at CB1 and 9.5 nM at CB2, a selectivity of almost 12x.[2]
The corresponding E or cis isomer is AM-905.
See also
References
- ↑ Busch-Petersen, Jakob; Hill, W. Adam; Fan, Pusheng; Khanolkar, Atmaram; Xie, Xuang-Qun; Tius, Marcus A.; Makriyannis, Alexandros (1996). "Unsaturated Side Chain β-11-Hydroxyhexahydrocannabinol Analogs". Journal of Medicinal Chemistry. 39 (19): 3790–3796. doi:10.1021/jm950934b. ISSN 0022-2623.
- ↑ Papahatjis DP, et al. Pharmacophoric requirements for cannabinoid side chains: multiple bond and C1'-substituted delta 8-tetrahydrocannabinols. Journal of Medicinal Chemistry. 1998 Mar 26;41(7):1195-200. PMID 9544219
This article is issued from Wikipedia - version of the 8/1/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.