Clinical data
ATC code None
Legal status
Legal status
PubChem (CID) 54576693
ChemSpider 45743462
Chemical and physical data
Formula C18H17ClF2N4O3
Molar mass 410.802 g/mol
3D model (Jmol) Interactive image

JNJ-42165279 is a drug developed by Janssen Pharmaceutica which acts as a potent and selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH), with an IC50 of 70 nM.[1] It is described as a covalently binding but slowly reversible selective inhibitor of FAAH.[2] JNJ-42165279 is being developed for the treatment of anxiety disorders and major depressive disorder. Clinical development has progressed as far as Phase II human trials with two studies in patients with mood disorders registered in[3][4]

In early 2016, a trial with a different FAAH inhibitor Bial's BIA 10-2474 resulted in a series of severe adverse events, including a death. In response, Janssen announced that it was temporarily suspending dosing in its two Phase II clinical trials with JNJ-42165279, describing the decision as "precautionary measure follows safety issue with different drug in class". Janssen was emphatic that no serious adverse events had been reported in any of the clinical trials with JNJ-42165279 to date. The suspension is to remain in effect until more information is available about the BIA 10-2474 study.[5]

See also


  1. Keith, John M.; Jones, William M.; Tichenor, Mark; Liu, Jing; Seierstad, Mark; Palmer, James A.; Webb, Michael; Karbarz, Mark; Scott, Brian P.; Wilson, Sandy J.; Luo, Lin; Wennerholm, Michelle L.; Chang, Leon; Rizzolio, Michele; Rynberg, Raymond; Chaplan, Sandra R.; Breitenbucher, J. Guy (2015). "Preclinical Characterization of the FAAH Inhibitor JNJ-42165279". ACS Medicinal Chemistry Letters. 6 (12): 1204. doi:10.1021/acsmedchemlett.5b00353. PMID 26713105.
  2. JNJ-42165279: selective and slowly reversible FAAH inhibitor. Central and Peripheral PK/PD.
  3. "A Safety and Efficacy Study of JNJ-42165279 in Participants With Social Anxiety Disorder (NCT02432703)". Registry. 29 April 2015. Retrieved 21 January 2016.
  4. "An Efficacy, Safety and Tolerability Study of JNJ-42165279 in Participants With Major Depressive Disorder With Anxious Distress (NCT02498392)". Registry. 13 July 2015. Retrieved 21 January 2016.
  5. "Janssen Research & Development, LLC Voluntarily Suspends Dosing in Phase 2 Clinical Trials of Experimental Treatment for Mood Disorders". 17 January 2016. Retrieved 21 January 2016.

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