Clinical data
ATC code none
Legal status
Legal status
  • ?
CAS Number 885490-15-3
ChemSpider 28501432
Chemical and physical data
Formula C25H33N3O4S
Molar mass 471.61 g/mol
3D model (Jmol) Interactive image

S-444,823 is a drug developed by Shionogi which is a cannabinoid agonist.[1] It was developed as an antipruritic, and has moderate selectivity for the CB2 subtype, having a CB2 affinity of 18nM, and 32x selectivity over the CB1 receptor. In animal studies it showed analgesic effects and strongly reduced itching responses, but without producing side effects such as sedation and catalepsy that are seen with centrally acting CB1 agonists.[2]

See also


  1. Arimura A. Novel Use of Cannabinoid Receptor Agonist. Patent WO 2005/016351
  2. Odan M, et al. Discovery of S-444823, a potent CB1/CB2 dual agonist as an antipruritic agent. Bioorganic and Medicinal Chemistry Letters. 2012 Apr 15;22(8):2898-901. PMID 22421019
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